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首页> Nature communications> Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis.

Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis.

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作者： Adekunle,Alabi ^[1] ; Xiao-Dan,Xia ^[1] ; Hong-Mei,Gu ^[2] ; Faqi,Wang ^[1] ; Shi-Jun,Deng ^[1] ; Nana,Yang ^[1] ; Ayinuer,Adijiang ^[3] ; Donna N,Douglas ^[1] ; Norman M,Kneteman ^[4] ; Yazhuo,Xue ^[4] ; Li,Chen ^[5] ; Shucun,Qin ^[5] ; Guiqing,Wang ^[5] ; Da-Wei,Zhang ^[2]

作者单位： The Department of Pediatrics and Group on the Molecular and Cell Biology of Lipids, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada. ^[1] Department of Orthopedics, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, China. ^[2] Experimental Center for Medical Research, Weifang Medical University, Weifang, China. ^[3] Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada. ^[4] Institute of Atherosclerosis in Shandong First Medical University (Shandong Academy of Medical Sciences), Taian, China. ^[5] The Department of Pediatrics and Group on the Molecular and Cell Biology of Lipids, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada. dzhang@ualberta.ca. ^[6]

主题词动物(Animals);载脂蛋白B100(Apolipoprotein B-100);载脂蛋白E类(Apolipoproteins E);动脉粥样硬化(Atherosclerosis);细胞系, 肿瘤(Cell Line, Tumor);胆固醇酯类(Cholesterol Esters);依赖病毒(Dependovirus);女(雌)性(Female);HEK293细胞(HEK293 Cells);Hep G2细胞(Hep G2 Cells);人类(Humans);脂蛋白类, LDL(Lipoproteins, LDL);男(雄)性(Male);基质金属蛋白酶14(Matrix Metalloproteinase 14);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);受体, LDL(Receptors, LDL)

DOI 10.1038/s41467-021-22167-3

PMID 33767172

发布时间 2021-04-17

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Nature communications

Nature communications

2021年12卷1期

1889页

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