Dual modes of CRISPR-associated transposon homing.

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第一作者： Makoto,Saito

第一单位： Howard Hughes Medical Institute, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

作者： Makoto,Saito ^[1] ; Alim,Ladha ^[1] ; Jonathan,Strecker ^[1] ; Guilhem,Faure ^[1] ; Edwin,Neumann ^[1] ; Han,Altae-Tran ^[1] ; Rhiannon K,Macrae ^[1] ; Feng,Zhang ^[2]

作者单位： Howard Hughes Medical Institute, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. ^[1] Howard Hughes Medical Institute, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: zhang@broadinstitute.org. ^[2]

关键词 CRISPR, CRISPR-associated transposases, CAST, RNA-guided DNA transposition, homing transposition, Type V-K Cas12k effector, Type I-B Cascade effector, Tn7, TnsD/TniQ, transposon target selectors

主题词细菌(Bacteria);细菌蛋白质类(Bacterial Proteins);DNA转座子(DNA Transposable Elements);DNA, 细菌(DNA, Bacterial);重组, 遗传(Recombination, Genetic);转座酶类(Transposases)

DOI 10.1016/j.cell.2021.03.006

PMID 33770501

发布时间 2024-01-04

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