换一批Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders.
第一作者：
Marta F,Nabais
第一单位：
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.;University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK.
作者：
Marta F,Nabais [1]
;
Simon M,Laws [2]
;
Tian,Lin [3]
;
Costanza L,Vallerga [4]
;
Nicola J,Armstrong [5]
;
Ian P,Blair [6]
;
John B,Kwok [7]
;
Karen A,Mather [8]
;
George D,Mellick [9]
;
Perminder S,Sachdev [10]
;
Leanne,Wallace [3]
;
Anjali K,Henders [3]
;
Ramona A J,Zwamborn [11]
;
Paul J,Hop [11]
;
Katie,Lunnon [12]
;
Ehsan,Pishva [12]
;
Janou A Y,Roubroeks [12]
;
Hilkka,Soininen [13]
;
Magda,Tsolaki [14]
;
Patrizia,Mecocci [15]
;
Simon,Lovestone [16]
;
Iwona,Kłoszewska [17]
;
Bruno,Vellas [18]
;
Australian Imaging Biomarkers and Lifestyle study [19]
;
Alzheimer’s Disease Neuroimaging Initiative [3]
;
Sarah,Furlong [20]
;
Fleur C,Garton [21]
;
Robert D,Henderson [22]
;
Susan,Mathers [23]
;
Pamela A,McCombe [24]
;
Merrilee,Needham [25]
;
Shyuan T,Ngo [26]
;
Garth,Nicholson [19]
;
Roger,Pamphlett [27]
;
Dominic B,Rowe [19]
;
Frederik J,Steyn [28]
;
Kelly L,Williams [29]
;
Tim J,Anderson [30]
;
Steven R,Bentley [9]
;
John,Dalrymple-Alford [31]
;
Javed,Fowder [32]
;
Jacob,Gratten [32]
;
Glenda,Halliday [33]
;
Ian B,Hickie [32]
;
Martin,Kennedy [3]
;
Simon J G,Lewis [34]
;
Grant W,Montgomery [28]
;
John,Pearson [35]
;
Toni L,Pitcher [3]
;
Peter,Silburn [3]
;
Futao,Zhang [36]
;
Peter M,Visscher [37]
;
Jian,Yang [37]
;
Anna J,Stevenson [37]
;
Robert F,Hillary [38]
;
Riccardo E,Marioni [38]
;
Sarah E,Harris [39]
;
Ian J,Deary [39]
;
Ashley R,Jones [39]
;
Aleksey,Shatunov [11]
;
Alfredo,Iacoangeli [11]
;
Wouter,van Rheenen [40]
;
Leonard H,van den Berg [39]
;
Pamela J,Shaw [41]
;
Cristopher E,Shaw [42]
;
Karen E,Morrison [11]
;
Ammar,Al-Chalabi [12]
;
Jan H,Veldink [43]
;
Eilis,Hannon [44]
;
Jonathan,Mill [45]
;
Naomi R,Wray ;
Allan F,McRae
作者单位：
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.;University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK.
[1]
School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Dr, Joondalup, WA, 6027, Australia.
[2]
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.
[3]
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.;Department of Internal Medicine, Erasmus MC, University Medical Center, 3015GD, Rotterdam, The Netherlands.
[4]
Murdoch University, 90 South St, Murdoch, WA, 6150, Australia.
[5]
Australian Centre for Precision Health, University of South Australia Cancer Research Institute, School of Health Sciences, University of South Australia, Adelaide, SA, 5001, Australia.
[6]
Brain and Mind Centre, Sydney Medical School, The University of Sydney, Sydney, Australia.
[7]
Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, 2031, Australia.;Neuroscience Research Australia Institute, Randwick, NSW, 2031, Australia.
[8]
Griffith Institute for Drug Discovery (GRIDD), Griffith University, Brisbane, Australia.
[9]
Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, 2031, Australia.;Neuropsychiatric Institute, The Prince of Wales Hospital, UNSW, Randwick, NSW, 2031, Australia.
[10]
Department of Neurology, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.
[11]
University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK.
[12]
Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland.
[13]
1st Department of Neurology, Memory and Dementia Unit, Aristotle University of Thessaloniki, Thessaloniki, Greece.
[14]
Department of Medicine, Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy.
[15]
Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
[16]
Medical University of Lodz, Lodz, Poland.
[17]
INSERM U 558, University of Toulouse, Toulouse, France.
[18]
Centre for Motor Neuron Disease Research, Macquarie University, Sydney, NSW, 2109, Australia.
[19]
Queensland Brain Institute, The University of Queensland, Brisbane, QLD, 4072, Australia.;Centre for Clinical Research, The University of Queensland, Brisbane, QLD, 4019, Australia.;Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, QLD, 4029, Australia.
[20]
Calvary Health Care Bethlehem, Parkdale, VIC, 3195, Australia.
[21]
Centre for Clinical Research, The University of Queensland, Brisbane, QLD, 4019, Australia.;Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, QLD, 4029, Australia.
[22]
Fiona Stanley Hospital, Perth, WA, 6150, Australia.;Notre Dame University, Fremantle, WA, 6160, Australia.;Institute for Immunology and Infectious Diseases, Murdoch University, Perth, WA, 6150, Australia.
[23]
Queensland Brain Institute, The University of Queensland, Brisbane, QLD, 4072, Australia.;Centre for Clinical Research, The University of Queensland, Brisbane, QLD, 4019, Australia.;The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4072, Australia.
[24]
ANZAC Research Institute, Concord Repatriation General Hospital, Sydney, NSW, 2139, Australia.
[25]
Discipline of Pathology and Department of Neuropathology, Brain and Mind Centre, The University of Sydney, Sydney, NSW, 2050, Australia.
[26]
Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, QLD, 4029, Australia.;School of Biomedical Sciences, The University of Queensland, Brisbane, QLD, 4072, Australia.
[27]
New Zealand Brain Research Institute, Christchurch, New Zealand.;Department of Medicine, University of Otago, Christchurch, New Zealand.
[28]
Eskitis Institute for Drug Discovery, Griffith University, Brisbane, Australia.
[29]
New Zealand Brain Research Institute, Christchurch, New Zealand.;School of Psychology, Speech and Hearing, University of Canterbury, Christchurch, New Zealand.
[30]
Mater Research, Translational Research Institute, Brisbane, Australia.;Mater Research Institute, The University of Queensland, Brisbane, Australia.
[31]
Brain and Mind Research Centre, Sydney Medical School, The University of Sydney, Sydney, Australia.
[32]
Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.
[33]
Department of Pathology, University of Otago, Christchurch, New Zealand.
[34]
Queensland Brain Institute, The University of Queensland, Brisbane, QLD, 4072, Australia.
[35]
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.;School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.;Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.
[36]
Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
[37]
Department of Psychology, Lothian Birth Cohorts group, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
[38]
Department of Basic and Clinical Neuroscience, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, SE5 9RX, UK.
[39]
SITraN, University of Sheffield, Sheffield, UK.
[40]
Queen's University Belfast, Belfast, Northern Ireland, UK.
[41]
Department of Basic and Clinical Neuroscience, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, SE5 9RX, UK.;King's College Hospital, London, SE5 9RS, UK.
[42]
University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK.;Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.
[43]
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.;Queensland Brain Institute, The University of Queensland, Brisbane, QLD, 4072, Australia.
[44]
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia. a.mcrae@uq.edu.au.
[45]
医学主题词
等位基因(Alleles);血细胞(Blood Cells);病例对照研究(Case-Control Studies);DNA甲基化(DNA Methylation);疾病易感性(Disease Susceptibility);后成说, 遗传(Epigenesis, Genetic);基因表达谱(Gene Expression Profiling);基因座(Genetic Loci);疾病遗传易感性(Genetic Predisposition to Disease);全基因组关联研究(Genome-Wide Association Study);人类(Humans);神经变性疾病(Neurodegenerative Diseases)
DOI
10.1186/s13059-021-02275-5
PMID
33771206
发布时间
2025-07-08
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Genome biology
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