Mapping Isoform Abundance and Interactome of the Endogenous TMPRSS2-ERG Fusion Protein by Orthogonal Immunoprecipitation-Mass Spectrometry Assays.

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作者： Zhiqiang,Fu ^[1] ; Yasmine,Rais ^[2] ; Tarek A,Bismar ^[3] ; M Eric,Hyndman ^[4] ; X Chris,Le ^[2] ; Andrei P,Drabovich ^[5]

作者单位： Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada; Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Environmental Science and Technology, Dalian University of Technology, Dalian, China. ^[1] Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada. ^[2] Department of Pathology and Laboratory Medicine, University of Calgary Cumming School of Medicine, and Alberta Precision Laboratories, Calgary, Alberta, Canada. ^[3] Division of Urology, Department of Surgery, Southern Alberta Institute of Urology, University of Calgary, Alberta, Canada. ^[4] Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada. Electronic address: andrei.drabovich@ualberta.ca. ^[5]

关键词 ERG interactome ERG protein isoforms TMPRSS2-ERG fusion VCaP cBAF complex canonical SWI/SNF complex mass spectrometry proteomics selected reaction monitoring