Cell-penetrating Alphabody protein scaffolds for intracellular drug targeting.

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作者： Erwin,Pannecoucke ^[1] ; Maaike,Van Trimpont ^[2] ; Johan,Desmet ^[3] ; Tim,Pieters ^[4] ; Lindy,Reunes ^[5] ; Lisa,Demoen ^[3] ; Marnik,Vuylsteke ^[4] ; Stefan,Loverix ^[3] ; Karen,Vandenbroucke ^[4] ; Philippe,Alard ^[3] ; Paula,Henderikx ^[4] ; Sabrina,Deroo ^[6] ; Franky,Baatz ^[5] ; Eric,Lorent ^[5] ; Sophie,Thiolloy ^[5] ; Klaartje,Somers ^[5] ; Yvonne,McGrath ^[5] ; Pieter,Van Vlierberghe ^[5] ; Ignace,Lasters ^[5] ; Savvas N,Savvides ^[5]

作者单位： VIB Center for Inflammation Research, 9052 Ghent, Belgium. ^[1] Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University, 9052 Ghent, Belgium. ^[2] Department of Biomolecular Medicine, Ghent University, Ghent, Belgium. ^[3] Cancer Research Institute Ghent (CRIG), Ghent, Belgium. ^[4] Complix N.V., 9052 Ghent, Belgium. ^[5] Gnomixx, 9090 Melle, Belgium. ^[6] Complix N.V., 9052 Ghent, Belgium. ignace.lasters@complix.com savvas.savvides@ugent.be. ^[7] VIB Center for Inflammation Research, 9052 Ghent, Belgium. ignace.lasters@complix.com savvas.savvides@ugent.be. ^[8]

主题词动物(Animals);细胞凋亡(Apoptosis);细胞系(Cell Line);细胞系, 肿瘤(Cell Line, Tumor);药物释放系统(Drug Delivery Systems);人类(Humans);小鼠(Mice);肿瘤(Neoplasms);肽类(Peptides)

DOI 10.1126/sciadv.abe1682

PMID 33771865

发布时间 2022-04-18

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Science advances

2021年7卷13期

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Cell-penetrating Alphabody protein scaffolds for intracellular drug targeting.

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Cell-penetrating Alphabody protein scaffolds for intracellular drug targeting.

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