High-Throughput Transcriptomic Analysis of Human Primary Hepatocyte Spheroids Exposed to Per- and Polyfluoroalkyl Substances as a Platform for Relative Potency Characterization.

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第一作者： Andrea,Rowan-Carroll

第一单位： Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch (HECSB) Health Canada, Ottawa, Ontario K1N 6N5, Canada.

作者： Andrea,Rowan-Carroll ^[1] ; Anthony,Reardon ^[1] ; Karen,Leingartner ^[1] ; Remi,Gagné ^[1] ; Andrew,Williams ^[1] ; Matthew J,Meier ^[1] ; Byron,Kuo ^[1] ; Julie,Bourdon-Lacombe ^[2] ; Ivy,Moffat ^[2] ; Richard,Carrier ^[2] ; Andy,Nong ^[1] ; Luigi,Lorusso ^[3] ; Stephen S,Ferguson ^[4] ; Ella,Atlas ^[1] ; Carole,Yauk ^[5]

作者单位： Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch (HECSB) Health Canada, Ottawa, Ontario K1N 6N5, Canada. ^[1] Water and Air Quality Bureau, Healthy Environments and Consumer Safety Branch (HECSB) Health Canada, Ottawa, Ontario K1N 6N5, Canada. ^[2] Chemicals and Environmental Health Management Bureau, Healthy Environments and Consumer Safety Branch (HECSB) Health Canada, Ottawa, Ontario K1N 6N5, Canada. ^[3] U.S. National Institute of Environmental Health Sciences (NIEHS), Ottawa, Ontario K1N 6N5, Canada. ^[4] Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch (HECSB) Health Canada, Ottawa, Ontario K1N 6N5, Canada.;Department of Biology, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada. ^[5]

关键词 PFAS TempO-Seq benchmark concentration bioactivity exposure ratio liver spheroids new approach methodology

主题词链烷磺酸类(Alkanesulfonic Acids);氟碳化合物(Fluorocarbons);肝细胞(Hepatocytes);人类(Humans)

DOI 10.1093/toxsci/kfab039

PMID 33772556

发布时间 2021-08-18

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准确一般字义偏差语意偏离译文作用小提交