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Discrepancies in metabolomic biomarker identification from patient-derived lung cancer revealed by combined variation in data pre-treatment and imputation methods.

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第一作者： Hunter A,Miller

第一单位： Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA.

作者： Hunter A,Miller ^[1] ; Ramy,Emam ^[2] ; Chip M,Lynch ^[3] ; Samuel,Bockhorst ^[4] ; Hermann B,Frieboes ^[5]

作者单位： Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA. ^[1] Department of Bioengineering, University of Louisville, Louisville, KY, USA. ^[2] Department of Computer Engineering and Computer Science, University of Louisville, Louisville, USA. ^[3] Department of Medicine, University of Louisville, Louisville, USA. ^[4] Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA. hbfrie01@louisville.edu.;James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA. hbfrie01@louisville.edu.;Center for Predictive Medicine, University of Louisville, Louisville, KY, USA. hbfrie01@louisville.edu.;Department of Bioengineering, University of Louisville, Lutz Hall 419, Louisville, KY, 40292, USA. hbfrie01@louisville.edu. ^[5]

关键词 Imputation methods Lung cancer Machine learning Metabolomics Multivariate statistical analysis Pre-treatment methods

医学主题词人类(Humans);肺肿瘤(Lung Neoplasms);代谢组学(Metabolomics);主成分分析(Principal Component Analysis)

DOI 10.1007/s11306-021-01787-2

PMID 33772663

发布时间 2024-04-02

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准确一般字义偏差语意偏离译文作用小提交