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首页> Frontiers in endocrinology> Patient-Derived Organoid Models of Human Neuroendocrine Carcinoma.

Patient-Derived Organoid Models of Human Neuroendocrine Carcinoma.

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作者： Krijn K,Dijkstra ^[1] ; José G,van den Berg ^[2] ; Fleur,Weeber ^[3] ; Joris,van de Haar ^[1] ; Arno,Velds ^[2] ; Sovann,Kaing ^[1] ; Dennis D G C,Peters ^[2] ; Ferry A L M,Eskens ^[4] ; Derk-Jan A,de Groot ^[1] ; Margot E T,Tesselaar ^[2] ; Emile E,Voest ^[5]

作者单位： Department of Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands. ^[1] Oncode Institute, Amsterdam, Netherlands. ^[2] Department of Pathology, Netherlands Cancer Institute, Amsterdam, Netherlands. ^[3] Central Genomics Facility, Netherlands Cancer Institute, Amsterdam, Netherlands. ^[4] Core Facility Molecular Pathology and Biobanking, Netherlands Cancer Institute, Amsterdam, Netherlands. ^[5] Department of Medical Oncology, Erasmus Medical Center, Rotterdam, Netherlands. ^[6] Department of Medical Oncology, University Medical Center Groningen, Groningen, Netherlands. ^[7] Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands. ^[8]

关键词 disease modeling extrapulmonary neuroendocrine carcinoma gastroenteropancreatic neuroendocrine carcinoma (GEP-NEC)organoids pre-clinical models

主题词细胞死亡(Cell Death);细胞系, 肿瘤(Cell Line, Tumor);顺铂(Cisplatin);DNA错配修复(DNA Mismatch Repair);基因剂量(Gene Dosage);人类(Humans);肠肿瘤(Intestinal Neoplasms);Ki-67抗原(Ki-67 Antigen);模型, 生物学(Models, Biological);突变(Mutation);神经内分泌瘤(Neuroendocrine Tumors);类器官(Organoids);胰腺肿瘤(Pancreatic Neoplasms);胃肿瘤(Stomach Neoplasms)

DOI 10.3389/fendo.2021.627819

PMID 33776923

发布时间 2022-12-07

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Frontiers in endocrinology

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