换一批
换一批Isorhapontigenin protects against doxorubicin-induced cardiotoxicity <i>via</i> increasing YAP1 expression.
作者：
关键词
AMPK, AMP-activated protein kinaseAP-1, anti-microbial proteinAREG, amphiregulinAUC/Dose, dose-normalized plasma exposuresAmphiregulinAng II, angiotensin IICO, cardiac outputCTGF, connective tissue growth factorCardiomyocytes apoptosisCardiotoxicityCmax/Dose, dose-normalized maximal plasma concentrationsConnective tissue growth factorDAB, 3,3′-diaminobenzidineDMEM, Dulbecco's modified Eagle's mediumDob, dobutamineDox, doxorubicinDoxorubicinEMT, epithelial mesenchymal transformationFOXO1, forkhead box class O1FS, fractional shorteningHE, hematoxylin–eosinISO, isoproterenolIsor, isorhapontigeninIsorhapontigeninLVAW;d, left ventricular end-diastolic anterior wall thicknessLVAW;s, left ventricular end-systolic anterior wall thicknessLVEF, left ventricular ejection fractionLVID;d, left ventricular end-diastolic internal diameterLVID;s, left ventricular end-systolic internal diameterLVPW;d, left ventricular end-diastolic posterior wall thicknessLVPW;s, left ventricular end-systolic posterior wall thicknessMAPK, mitogen-activated protein kinaseMI, myocardial infarctionNF-κB, nuclear factor kappa-BNRCMs, neonatal rat cardiomyocytesP2Y12 receptor, ADP receptorPGC-1α, peroxisome proliferator-activated receptor γ coactivator-1αPMSF, phenylmethanesulfonyl fluoridePVDF, polyvinylidene fluorideROS, reactive oxygen speciesSD, Sprague–DawleySDS-PAGE, sodium dodecyl sulfate-polyacrylamide gel electrophoresisSESN2, sestrin2TCF4, T-cell factor 4TEAD, TEA domain transcription factor proteinsTEAD1TUNEL, TdT-mediated dUTP nick end labelingWGA, wheat germ agglutininYAP1YAP1, Yes-associated protein 1qRT-PCR, quantitative real-time polymerase chain reactionsgRNAs, sequence guiding RNAsΔψm, mitochondrial membrane potential
DOI
10.1016/j.apsb.2020.10.017
PMID
33777675
发布时间
2021-03-30
- 浏览2
Acta pharmaceutica Sinica. B
2021年11卷3期
680-693页
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