换一批Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing.
第一作者：
Zhiru,Wang
第一单位：
School of Pharmaceutical Sciences, Zhengzhou University; Co-Innovation Center of Henan Province for New Drug R&D and Preclinical Safety; State Key Laboratory of Esophageal Cancer Prevention and Treatment, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education of China, Zhengzhou 450001 China.;Department of Pathology, the Norwegian Radium Hospital, Oslo University Hospital; Department of Pathology, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo 0379, Norway.
作者：
关键词
BCA, bicinchoninic acidCHX, cycloheximideCSN5, COP9 signalosome 5Cancer biologyDUB, deubiquitinating enzymesEBNA1, Epstein–Barr nuclear antigen 1EpigeneticsFDA, U.S. Food and Drug AdministrationFOXO4, forkhead box O4GC, gastric cancerGEPIA, Gene-Expression Profiling Interactive AnalysisGastric cancerH2O2, hydrogen peroxidaseHAUSP, herpes virus-associated ubiquitin-specific proteaseHDN, well differentiated matched adjacent normal tissuesHDT, well differentiated tumor tissuesICP0, infected cell protein 0IL-2, interleukin 2ImmunosuppressionImmunotherapyMDM2, murine double minute-2PBMC, peripheral blood mononuclear cellsPBS, phosphate buffer salinePD-1, programmed cell death protein 1PD-L1PD-L1, programmed death ligand-1PDN, poor differentiated matched adjacent normal tissuesPDT, poor differentiated tumor tissuesPTMs, post-translational modificationsRIPA, radioimmunoprecipitationTCGA, the Cancer Genome AtlasTCR, T cell receptorTILs, tumor-infiltrating T cellsUSP18, ubiquitin specific peptidase 18USP22, ubiquitin specific peptidase 22USP38, ubiquitin specific peptidase 38USP7USP7, ubiquitin-specific processing protease 7USP9X, ubiquitin specific peptidase 9 X-linkedUbiquitinationWB, Western blottingirAEs, immune-related adverse effectsqRT-PCR, quantitative real time polymerase chain reaction
DOI
10.1016/j.apsb.2020.11.005
PMID
33777676
发布时间
2021-03-30
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Acta pharmaceutica Sinica. B
2021年11卷3期
694-707页
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