换一批Functional metabolomics reveal the role of AHR/GPR35 mediated kynurenic acid gradient sensing in chemotherapy-induced intestinal damage.
第一作者：
Di,Wang
第一单位：
Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing 210009, China.
作者：
关键词
1-MT, 1-methyl-tryptophanAG, AG490AHRAHR, aryl hydrocarbon receptorARNT, aryl hydrocarbon receptor nuclear translocatorBCA, bicinchoninic acidBSA, bovine serum albuminCH, CH223191CPT-11, irinotecanCYP1A1, cytochrome P450 1A1DAI, disease activity indexDMSO, dimethyl sulfoxideDPP-4, dipeptidyl peptidase-4DRE, dioxin response elementsDSS, dextran sulphate sodiumDens-Cl, N-diethyl-amino naphthalene-1-sulfonyl chlorideDns-Cl, N-dimethyl-amino naphthalene-1-sulfonyl chlorideECL, enhanced chemiluminescenceELISA, enzyme-linked immunosorbent assayERK1/2, extracellular regulated protein kinases 1/2ESI, electrospray ionizationFBS, fetal bovine serumGE, gastric emptyingGFP, green fluorescence proteinGI, gastrointestinal transitGPR35GPR35, G protein-coupled receptor 35Gradually sensingHE, hematoxylin and eosinHRP, horseradish peroxi-daseIBD, inflammatory bowel diseaseIDO1, indoleamine 2,3-dioxygenase 1IL-6, interleukin-6IS, internal standardIntestinal toxicityJAK2, janus kinase 2KA, kynurenic acidKAT, kynurenine aminotransferaseKYN, kynurenineKynurenine pathwayLC–MS, liquid chromatography–mass spectrometryLPS, lipopolysaccharidesLinag, linagliptinMOE, molecular operating environmentMOI, multiplicity of infectionMRM, multiple-reaction monitoringMTT, thiazolyl blue tetrazolium bromidePBS, phosphate buffer salinePDB, protein data bankPDE5, phosphodiesterase type-5PF, PF-04859989PMA, phorbol 12-myristate 13-acetatePMSF, phenylmethylsulfonyl fluorideRIPA, radioimmunoprecipitationRPKM, reads per kilobase per million mapped readsRPMI 1640, Roswell Park Memorial Institute 1640RT-PCR, real-time polymerase chain reactionSTAT3, signal transducer and activator of transcription 3Trp, tryptophanVCR, vincristineVard, vardenafil
DOI
10.1016/j.apsb.2020.07.017
PMID
33777681
发布时间
2021-03-30
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Acta pharmaceutica Sinica. B
2021年11卷3期
763-780页
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