换一批Toxicity of diclofenac sodium salt in Yucatan minipigs <i>(Sus scrofa)</i> following 4 weeks of daily intramuscular administration.
第一作者：
Hyung-Sun,Kim
第一单位：
Animal Model Research Group, Jeonbuk Branch Institute, Korea Institute of Toxicology, Jeongup, Jeonbuk, 56212, Republic of Korea.
作者：
关键词
4-Week repeated toxicityAAALAC, association for assessment and accreditation of laboratory animal careALT, alanine aminotransferaseAP, Alkaline phosphataseAST, aspartate aminotransferaseAUC, area under the concentration-time curveBUN, blood urea nitrogenBW, body weightCAS, chemical abstracts serviceCL, clearanceCOX, cyclooxygenaseCREA, creatineCRO, contract research organizationCV, coefficients of variationCmax, maximum plasma concentrationDSS, diclofenac sodium saltDiclofenac sodium saltECG, ElectrocardiogramGI, gastrointestinalGLP, good laboratory practiceH&E, hematoxylin and eosinHED, human effective doseHR, heart rateIACUC, institutional animal care and use committeeMinipigNDA, new drug applicationNOAEL, No-observed-adverse-effect levelsNSAIDs, nonsteroidal anti-inflammatory drugsNo-observed-adverse-effect levelRBC, red blood cellSD, standard deviationTK, toxicokineticsTP, total proteinTmax, time to maximum plasma concentrationWBC, white blood cellaVF, augmented vector footaVL, augmented vector leftaVR, augmented vector right
DOI
10.1016/j.toxrep.2021.02.022
PMID
33777702
发布时间
2021-03-30
- 浏览2
Toxicology reports
2021年8卷
557-570页
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