Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3<i>H</i>)-quinazolinone Aryl Urea pan-RAF Kinase Inhibitor.-论文-万方医学网

第一作者： Malcolm P,Huestis

第一单位： Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.

作者： Malcolm P,Huestis ^[1] ; Darlene,Dela Cruz ^[2] ; Antonio G,DiPasquale ^[3] ; Matthew R,Durk ^[4] ; Charles,Eigenbrot ^[5] ; Paul,Gibbons ^[1] ; Alberto,Gobbi ^[1] ; Thomas L,Hunsaker ^[2] ; Hank,La ^[4] ; Dennis H,Leung ^[3] ; Wendy,Liu ^[1] ; Shiva,Malek ^[6] ; Mark,Merchant ^[2] ; John G,Moffat ^[7] ; Christine S,Muli ^[3] ; Christine J,Orr ^[2] ; Brendan T,Parr ^[1] ; Frances,Shanahan ^[6] ; Christopher J,Sneeringer ^[7] ; Weiru,Wang ^[5] ; Ivana,Yen ^[6] ; Jianping,Yin ^[5] ; Michael,Siu ^[1] ; Joachim,Rudolph ^[1]

作者单位： Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States. ^[1] Translational Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States. ^[2] Small Molecule Pharmaceutical Sciences, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States. ^[3] Drug Metabolism and Pharmacokinetics, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States. ^[4] Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States. ^[5] Molecular Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States. ^[6] Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States. ^[7]

医学主题词动物(Animals);吖丁啶类(Azetidines);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);结晶学, X线(Crystallography, X-Ray);狗(Dogs);复方合剂(Drug Combinations);药物协同作用(Drug Synergism);女(雌)性(Female);人类(Humans);小鼠, 裸(Mice, Nude);分子结构(Molecular Structure);突变(Mutation);肿瘤(Neoplasms);苯脲化合物(Phenylurea Compounds);哌啶类(Piperidines);蛋白质结合(Protein Binding);蛋白激酶抑制剂(Protein Kinase Inhibitors);喹唑啉酮类(Quinazolinones);构效关系(Structure-Activity Relationship);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays);raf激酶类(raf Kinases);小鼠(Mice)

DOI 10.1021/acs.jmedchem.0c02085

PMID 33780623

发布时间 2024-02-26

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Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3<i>H</i>)-quinazolinone Aryl Urea pan-RAF Kinase Inhibitor.

Journal of medicinal chemistry

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Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3<i>H</i>)-quinazolinone Aryl Urea pan-RAF Kinase Inhibitor.

Journal of medicinal chemistry

相似文献

同项目论文

Journal of medicinal chemistry

相关期刊

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