Myeloproliferative neoplasm-driving Calr frameshift promotes the development of pulmonary hypertension in mice.

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作者： Keiji,Minakawa ^[1] ; Tetsuro,Yokokawa ^[2] ; Koki,Ueda ^[1] ; Osamu,Nakajima ^[3] ; Tomofumi,Misaka ^[2] ; Yusuke,Kimishima ^[2] ; Kento,Wada ^[2] ; Yusuke,Tomita ^[2] ; Saori,Miura ^[1] ; Yuka,Sato ^[1] ; Kosaku,Mimura ^[1] ; Koichi,Sugimoto ^[2] ; Kazuhiko,Nakazato ^[4] ; Kenneth E,Nollet ^[2] ; Kazuei,Ogawa ^[1] ; Takayuki,Ikezoe ^[5] ; Yuko,Hashimoto ^[5] ; Yasuchika,Takeishi ^[6] ; Kazuhiko,Ikeda ^[2]

作者单位： Department of Blood Transfusion and Transplantation Immunology, School of Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 960-1295, Japan. ^[1] Department of Cardiovascular Medicine, School of Medicine, Fukushima Medical University, Fukushima, Japan. ^[2] Center for Molecular Genetics, Yamagata University, Yamagata, Japan. ^[3] Department of Pulmonary Hypertension, School of Medicine, Fukushima Medical University, Fukushima, Japan. ^[4] Department of Hematology, School of Medicine, Fukushima Medical University, Fukushima, Japan. ^[5] Department of Diagnostic Pathology, School of Medicine, Fukushima Medical University, Fukushima, Japan. ^[6] Department of Blood Transfusion and Transplantation Immunology, School of Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 960-1295, Japan. kazu-ike@fmu.ac.jp. ^[7]

关键词 CALR Essential thrombocythemia Macrophage Myeloproliferative neoplasms Pulmonary hypertension

主题词动物(Animals);移码突变(Frameshift Mutation);人类(Humans);高血压, 肺性(Hypertension, Pulmonary);小鼠(Mice);骨髓增殖性疾病(Myeloproliferative Disorders)

DOI 10.1186/s13045-021-01064-8

PMID 33785036

发布时间 2021-09-15

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