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Solubility, Permeability, Anti-Inflammatory Action and In Vivo Pharmacokinetic Properties of Several Mechanochemically Obtained Pharmaceutical Solid Dispersions of Nimesulide.

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第一作者： Wei,Wei

第一单位： National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.

作者： Wei,Wei ^[1] ; Veronica I,Evseenko ^[2] ; Mikhail V,Khvostov ^[3] ; Sergey A,Borisov ^[4] ; Tatyana G,Tolstikova ^[4] ; Nikolay E,Polyakov ^[5] ; Aleksandr V,Dushkin ^[6] ; Wenhao,Xu ^[1] ; Lu,Min ^[1] ; Weike,Su ^[1]

作者单位： National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China. ^[1] Institute of Solid State Chemistry and Mechanochemistry, Kutateladze, 18, Novosibirsk 630128, Russia. ^[2] Institute of Solid State Chemistry and Mechanochemistry, Kutateladze, 18, Novosibirsk 630128, Russia.;N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Lavrentiev Avenue 9, Novosibirsk 630090, Russia. ^[3] N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Lavrentiev Avenue 9, Novosibirsk 630090, Russia. ^[4] Institute of Solid State Chemistry and Mechanochemistry, Kutateladze, 18, Novosibirsk 630128, Russia.;Voevodsky Institute of Chemical Kinetics and Combustion, Institutskaya Str. 3, Novosibirsk 630090, Russia. ^[5] National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.;Institute of Solid State Chemistry and Mechanochemistry, Kutateladze, 18, Novosibirsk 630128, Russia. ^[6]

关键词 anti-inflammatory action bioavailability complexation disodium salt of glycyrrhizic acid hydroxypropyl-β-cyclodextrin intrinsic solubility magnesium carbonate micelles nimesulide pharmacokinetics polysaccharide arabinogalactan solid pharmaceutical dispersions supramolecular complexes