Metabolite Profiling and Characterization of LW6, a Novel HIF-1α Inhibitor, as an Antitumor Drug Candidate in Mice.

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第一作者： Kiho,Lee

第一单位： Department of Pharmacy, College of Pharmacy, Korea University, Sejong 30019, Korea.

作者： Kiho,Lee ^[1] ; Ji-Yoon,Lee ^[2] ; Kyeong,Lee ^[3] ; Cho-Rock,Jung ^[4] ; Min Ju,Kim ^[5] ; Jung Ah,Kim ^[6] ; Dong Gu,Yoo ^[6] ; Eun Jin,Shin ^[6] ; Soo Jin,Oh ^[2]

作者单位： Department of Pharmacy, College of Pharmacy, Korea University, Sejong 30019, Korea. ^[1] Asan Medical Center, Asan Institute for Life Sciences, Seoul 05505, Korea. ^[2] BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University-Seoul, Goyang 10326, Korea. ^[3] Gene Therapy Unit, KRIBB, Daejeon 34141, Korea. ^[4] Laboratory Animal Resource Center, KRIBB, Chungbuk 28116, Korea. ^[5] Asan Medical Center, Department of Medical Science, Asan Medical Institute of Convergence Science and Technology, University of Ulsan College of Medicine, Seoul 05505, Korea. ^[6]

关键词 LW6 hybrid triple quadrupole-linear ion trap mass spectrometer hypoxia-inducible factor-1α metabolite identification predictive multiple reaction monitoring-information dependent acquisition-enhanced product ion