首页> International journal of molecular sciences> Synthesis and Hybrid SAR Property Modeling of Novel Cholinesterase Inhibitors.

Synthesis and Hybrid SAR Property Modeling of Novel Cholinesterase Inhibitors.

导出 OA

翻译打印收藏纠错

第一作者： Jiri,Kos

第一单位： Regional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacky University, Slechtitelu 27, 78371 Olomouc, Czech Republic.

作者： Jiri,Kos ^[1] ; Violetta,Kozik ^[2] ; Dominika,Pindjakova ^[3] ; Timotej,Jankech ^[4] ; Adam,Smolinski ^[5] ; Sarka,Stepankova ^[6] ; Jan,Hosek ^[7] ; Michal,Oravec ^[8] ; Josef,Jampilek ^[9] ; Andrzej,Bak ^[2]

作者单位： Regional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacky University, Slechtitelu 27, 78371 Olomouc, Czech Republic. ^[1] Department of Chemistry, University of Silesia, Szkolna 9, 40007 Katowice, Poland. ^[2] Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University, Ilkovicova 6, 842 15 Bratislava, Slovakia. ^[3] Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University, Ilkovicova 6, 842 15 Bratislava, Slovakia.;NT-LAB o.z., Teplicka 35, 92101 Piestany, Slovakia. ^[4] GiG Research Institute, Pl. Gwarkow 1, 40166 Katowice, Poland. ^[5] Department of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentska 573, 53210 Pardubice, Czech Republic. ^[6] Department of Pharmacology and Toxicology, Veterinary Research Institute, Hudcova 296/70, 62100 Brno, Czech Republic. ^[7] Global Change Research Institute CAS, Belidla 986/4a, 60300 Brno, Czech Republic. ^[8] Regional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacky University, Slechtitelu 27, 78371 Olomouc, Czech Republic.;Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University, Ilkovicova 6, 842 15 Bratislava, Slovakia. ^[9]

关键词 4-aminosalicylanilides CoMSA carbamate synthesis cholinesterase inhibition lipophilicity molecular docking similarity-activity landscape index