Design and Synthesis of New Withaferin A Inspired Hedgehog Pathway Inhibitors.

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第一作者： Elisa,Bonandi

第一单位： Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133, Milan, Italy.

作者： Elisa,Bonandi ^[1] ; Mattia,Mori ^[2] ; Paola,Infante ^[3] ; Irene,Basili ^[4] ; Lucia,Di Marcotullio ^[5] ; Andrea,Calcaterra ^[6] ; Federica,Catti ^[7] ; Bruno,Botta ^[6] ; Daniele,Passarella ^[1]

作者单位： Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133, Milan, Italy. ^[1] Department of Biotechnology, Chemistry and Pharmacy Università degli Studi di Siena, Via Aldo Moro 2, 53100, Siena, Italy. ^[2] Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161, Rome, Italy. ^[3] Department of Molecular Medicine, University La Sapienza, Roma, Viale Regina Elena 291, 00161, Roma, Italy. ^[4] Department of Molecular Medicine, University La Sapienza, Roma, Viale Regina Elena 291, 00161, Roma, Italy.;Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Molecular Medicine, University La Sapienza, Viale Regina Elena 291, 00161, Roma, Italy. ^[5] Department of Chemistry and Technology of Drugs, University La Sapienza, Roma, Piazzale Aldo Moro 5, 00185, Rome, Italy. ^[6] Arkansas State University, Campus Querétaro Carretera Estatal 100, km 17.5. C.P., 76270 Municipio de Colón, Querétaro, México. ^[7]

关键词 2-piperidine ethanol Hedgehog inhibitors Hedgehog signalling pathway natural products withaferin A

主题词抗肿瘤药(Antineoplastic Agents);猬蛋白质类(Hedgehog Proteins);信号传导(Signal Transduction);醉茄内酯类(Withanolides)

DOI 10.1002/chem.202100315

PMID 33811701

发布时间 2023-11-07

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准确一般字义偏差语意偏离译文作用小提交