Multi-gene custom panels for the characterisation of metastatic colorectal carcinoma in clinical practice: express the role of <i>PIK3CA</i> mutations.

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作者： Dario,de Biase ^[1] ; Umberto,Malapelle ^[2] ; Antonio,De Leo ^[3] ; Thais,Maloberti ^[2] ; Michela,Visani ^[4] ; Pasquale,Pisapia ^[4] ; Giorgia,Acquaviva ^[4] ; Francesco,Pepe ^[5] ; Gianluca,Russo ^[2] ; Antonino,Iaccarino ^[4] ; Annalisa,Pession ^[6] ; Giovanni,Tallini ^[5] ; Giancarlo,Troncone ^[5]

作者单位： Department of Pharmacy and Biotechnology, Molecular Diagnostic Unit, University of Bologna, Bologna, Italy dario.debiase@unibo.it umberto.malapelle@unina.it. ^[1] Division of Molecular Pathology Laboratory, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. ^[2] Department of Public Health, University Federico II of Naples, Napoli, Italy dario.debiase@unibo.it umberto.malapelle@unina.it. ^[3] Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale), Molecular Diagnostic Unit, University of Bologna, Azienda USL di Bologna, Bologna, Italy. ^[4] Department of Public Health, University Federico II of Naples, Napoli, Italy. ^[5] Sanità Pubblica, University of Naples Federico II, Napoli, Italy. ^[6] Department of Pharmacy and Biotechnology, Molecular Diagnostic Unit, University of Bologna, Bologna, Italy. ^[7]

关键词 DNA colorectal cancer diagnostic techniques and procedures molecular oncogenes pathology

主题词 I类磷脂酰肌醇3-激酶类(Class I Phosphatidylinositol 3-Kinases);结直肠肿瘤(Colorectal Neoplasms);基因, ras(Genes, ras);人类(Humans);突变(Mutation);原癌基因蛋白质B-raf(Proto-Oncogene Proteins B-raf);原癌基因蛋白质类p21(ras)(Proto-Oncogene Proteins p21(ras))

DOI 10.1136/jclinpath-2021-207468

PMID 33820865

发布时间 2022-06-21

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