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A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection.

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第一作者： Panpan,Zhou

第一单位： Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.;IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.;Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.

作者： Panpan,Zhou ^[1] ; Meng,Yuan ^[2] ; Ge,Song ^[1] ; Nathan,Beutler ^[3] ; Namir,Shaabani ^[3] ; Deli,Huang ^[3] ; Wan-Ting,He ^[1] ; Xueyong,Zhu ^[2] ; Sean,Callaghan ^[1] ; Peter,Yong ^[1] ; Fabio,Anzanello ^[1] ; Linghang,Peng ^[3] ; James,Ricketts ^[3] ; Mara,Parren ^[3] ; Elijah,Garcia ^[3] ; Stephen A,Rawlings ^[4] ; Davey M,Smith ^[4] ; David,Nemazee ^[3] ; John R,Teijaro ^[3] ; Thomas F,Rogers ^[5] ; Ian A,Wilson ^[6] ; Dennis R,Burton ^[7] ; Raiees,Andrabi ^[1]

作者单位： Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.;IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.;Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA. ^[1] Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. ^[2] Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA. ^[3] Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA. ^[4] Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.;Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA. ^[5] Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.;IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.;Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.;Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. ^[6] Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.;IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.;Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.;Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA. ^[7]

DOI 10.1101/2021.03.30.437769

PMID 33821273

发布时间 2024-12-07

基金项目

P30 AI036214/AI/NIAID NIH HHS/United States P41 GM103393/GM/NIGMS NIH HHS/United States P41 RR001209/RR/NCRR NIH HHS/United States T32 AI007384/AI/NIAID NIH HHS/United States

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A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection.

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A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection.

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