Substantial anti-gout effect conferred by common and rare dysfunctional variants of URAT1/SLC22A12.

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作者： Yu,Toyoda ^[1] ; Yusuke,Kawamura ^[2] ; Akiyoshi,Nakayama ^[2] ; Hirofumi,Nakaoka ^[2] ; Toshihide,Higashino ^[3] ; Seiko,Shimizu ^[4] ; Hiroshi,Ooyama ^[2] ; Keito,Morimoto ^[2] ; Naohiro,Uchida ^[5] ; Ryuichiro,Shigesawa ^[1] ; Kenji,Takeuchi ^[1] ; Ituro,Inoue ^[1] ; Kimiyoshi,Ichida ^[6] ; Hiroshi,Suzuki ^[3] ; Nariyoshi,Shinomiya ^[7] ; Tappei,Takada ^[8] ; Hirotaka,Matsuo ^[1]

作者单位： Department of Pharmacy, The University of Tokyo Hospital, Tokyo. ^[1] Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama. ^[2] Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Mishima, Shizuoka. ^[3] Department of Cancer Genome Research, Sasaki Institute, Sasaki Foundation. ^[4] Ryougoku East Gate Clinic, Tokyo. ^[5] Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Aichi. ^[6] Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences. ^[7] Division of Kidney and Hypertension, Jikei University School of Medicine, Tokyo, Japan. ^[8]

关键词 Common Disease Common Variant hypothesis Common Disease Multiple Rare Variant hypothesis genetic risk factor gout susceptibility urate reabsorption transporter