Opportunities and Challenges in Developing a <i>Cryptosporidium</i> Controlled Human Infection Model for Testing Antiparasitic Agents.

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作者： Rajiv S,Jumani ^[1] ; Johanne,Blais ^[1] ; Hanns-Christian,Tillmann ^[2] ; Florencia,Segal ^[3] ; Dean,Wetty ^[3] ; Christian,Ostermeier ^[4] ; Natko,Nuber ^[4] ; Jay,Lakshman ^[5] ; Natasha,Aziz ^[1] ; Richa,Chandra ^[5] ; Wilbur H,Chen ^[6] ; Cynthia L,Chappell ^[7] ; Thierry T,Diagana ^[1] ; Ujjini H,Manjunatha ^[1]

作者单位： Novartis Institute for Tropical Diseases, Novartis Institutes for BioMedical Research, Inc., Emeryville, California 94608-2916, United States. ^[1] Novartis Institutes for BioMedical Research, Inc., Translational Medicine, 4056 Basel, Switzerland. ^[2] Novartis Institutes for BioMedical Research, Inc., Cambridge, Massachusetts 02139-4133, United States. ^[3] Novartis Pharma AG, 4002 Basel, Switzerland. ^[4] Novartis Pharmaceuticals Corporation, East Hanover, New Jersey 07936, United States. ^[5] Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States. ^[6] The University of Texas School of Public Health Houston, Texas 77225-0186, United States. ^[7]

关键词 CHIM Cryptosporidium antiparasitic agent cryptosporidiosis diarrhea drug discovery human-challenge model pediatric development

主题词成年人(Adult);抗寄生虫药(Antiparasitic Agents);儿童(Child);儿童, 学龄前(Child, Preschool);隐孢子虫病(Cryptosporidiosis);隐孢子虫属(Cryptosporidium);腹泻(Diarrhea);人类(Humans);疟疾(Malaria)

DOI 10.1021/acsinfecdis.1c00057

PMID 33822577

发布时间 2021-06-23

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ACS infectious diseases

2021年7卷5期

959-968页

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Opportunities and Challenges in Developing a <i>Cryptosporidium</i> Controlled Human Infection Model for Testing Antiparasitic Agents.

ACS infectious diseases

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Opportunities and Challenges in Developing a <i>Cryptosporidium</i> Controlled Human Infection Model for Testing Antiparasitic Agents.

ACS infectious diseases

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ACS infectious diseases

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