Rational thermostabilisation of four-helix bundle dimeric de novo proteins.

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作者： Shin,Irumagawa ^[1] ; Kaito,Kobayashi ^[2] ; Yutaka,Saito ^[3] ; Takeshi,Miyata ^[4] ; Mitsuo,Umetsu ^[4] ; Tomoshi,Kameda ^[5] ; Ryoichi,Arai ^[6]

作者单位： Department of Science and Technology, Graduate School of Medicine, Science and Technology, Shinshu University, Ueda, Nagano, 386-8567, Japan. ^[1] Department of Biomolecular Innovation, Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, Matsumoto, Nagano, 390-8621, Japan. ^[2] Department of Applied Biology, Faculty of Textile Science and Technology, Shinshu University, Ueda, Nagano, 386-8567, Japan. ^[3] Artificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo, 135-0064, Japan. ^[4] AIST-Waseda University Computational Bio Big-Data Open Innovation Laboratory (CBBD-OIL), Tokyo, 169-8555, Japan. ^[5] Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, 277-8561, Japan. ^[6] Department of Biochemistry and Biotechnology, Faculty of Agriculture, Kagoshima University, Kagoshima, 890-0065, Japan. ^[7] Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, Sendai, 980-8579, Japan. ^[8] Department of Science and Technology, Graduate School of Medicine, Science and Technology, Shinshu University, Ueda, Nagano, 386-8567, Japan. rarai@shinshu-u.ac.jp. ^[9] Department of Biomolecular Innovation, Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, Matsumoto, Nagano, 390-8621, Japan. rarai@shinshu-u.ac.jp. ^[10] Department of Applied Biology, Faculty of Textile Science and Technology, Shinshu University, Ueda, Nagano, 386-8567, Japan. rarai@shinshu-u.ac.jp. ^[11]