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Fibroblast growth factor induced Ucp1 expression in preadipocytes requires PGE2 biosynthesis and glycolytic flux.

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第一作者： Thomas,Gantert

第一单位： Department of Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.

作者： Thomas,Gantert ^[1] ; Fiona,Henkel ^[2] ; Christine,Wurmser ^[3] ; Josef,Oeckl ^[1] ; Lena,Fischer ^[1] ; Mark,Haid ^[4] ; Jerzy,Adamski ^[5] ; Julia,Esser-von Bieren ^[2] ; Martin,Klingenspor ^[6] ; Tobias,Fromme ^[1]

作者单位： Department of Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany. ^[1] Center of Allergy and Environment (ZAUM), Helmholtz Center Munich, Technical University of Munich, Munich, Germany. ^[2] Department of Animal Breeding, TUM School of Life Sciences, Technical University of Munich, Freising, Germany. ^[3] Research Unit Molecular Endocrinology and Metabolism, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany. ^[4] Research Unit Molecular Endocrinology and Metabolism, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany.;German Center for Diabetes Research (DZD), Neuherberg, Germany.;Institute of Experimental Genetics, Center of Life and Food Sciences Weihenstephan, Technical University of Munich, Freising, Germany.;Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. ^[5] Department of Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.;EKFZ-Else Kröner-Fresenius Center for Nutritional Medicine, Technical University of Munich, Freising, Germany.;ZIEL-Institute for Food & Health, Technical University of Munich, Freising, Germany. ^[6]

关键词 Fgf signaling Fgf8 PGE2 Ucp1 glucose metabolism glycolysis paracrine fibroblast growth factor preadipocyte prostaglandin uncoupling protein 1