Prodrug-type antisense oligonucleotides with enhanced nuclease stability and anti-tumour effects.

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作者： Hongqian,Ren ^[1] ; Zhe,Zhang ^[2] ; Wei,Zhang ^[1] ; Xuesong,Feng ^[3] ; Liang,Xu ^[4]

作者单位： State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing 100850, China. ^[1] China Medical University, School of Pharmacy, Shenyang 110122, China. ^[2] China Medical University, School of Pharmacy, Shenyang 110122, China. Electronic address: voncedar@126.com. ^[3] State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing 100850, China. Electronic address: xuliang24998@yahoo.com. ^[4]

关键词 Anti-tumour Antisense oligonucleotides Disulphide Hairpin Prodrug Stability

主题词核酸构象(Nucleic Acid Conformation);核酸类(Nucleic Acids);寡核苷酸类(Oligonucleotides);寡核苷酸类, 反义(Oligonucleotides, Antisense);药物前体(Prodrugs)

DOI 10.1016/j.ejps.2021.105832

PMID 33826934

发布时间 2021-06-21

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