Enhanced Solubility and Bioavailability of Dolutegravir by Solid Dispersion Method: In Vitro and In Vivo Evaluation-a Potential Approach for HIV Therapy.

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第一作者： Sunita,Chaudhary

第一单位： Department of Pharmaceutics, Arihant School of Pharmacy & BRI, Adalaj, Gandhinagar, 382421, India.

作者： Sunita,Chaudhary ^[1] ; Anroop B,Nair ^[2] ; Jigar,Shah ^[3] ; Bapi,Gorain ^[4] ; Shery,Jacob ^[5] ; Hiral,Shah ^[1] ; Vimal,Patel ^[3]

作者单位： Department of Pharmaceutics, Arihant School of Pharmacy & BRI, Adalaj, Gandhinagar, 382421, India. ^[1] Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, 31982, Saudi Arabia. banroop@gmail.com. ^[2] Department of Pharmaceutics, Institute of Pharmacy, Nirma University, Ahmedabad, 382481, India. ^[3] School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, 47500, Subang Jaya, Selangor, Malaysia.;Centre for Drug Delivery and Molecular Pharmacology, Faculty of Health and Medical Sciences, Taylor's University, 47500, Subang Jaya, Selangor, Malaysia. ^[4] Department of Pharmaceutical Sciences, College of Pharmacy, Gulf Medical University, Ajman, 4184, United Arab Emirates. ^[5]

关键词 Dolutegravir pharmacokinetics study solid dispersion solid-state characterization solvent evaporation technique