换一批Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19.
第一作者：
Liam,Gaziano
第一单位：
Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.;BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
作者：
Liam,Gaziano [1]
;
Claudia,Giambartolomei [2]
;
Alexandre C,Pereira [3]
;
Anna,Gaulton [4]
;
Daniel C,Posner [5]
;
Sonja A,Swanson [6]
;
Yuk-Lam,Ho [5]
;
Sudha K,Iyengar [7]
;
Nicole M,Kosik [5]
;
Marijana,Vujkovic [8]
;
David R,Gagnon [9]
;
A Patrícia,Bento [4]
;
Inigo,Barrio-Hernandez [10]
;
Lars,Rönnblom [11]
;
Niklas,Hagberg [11]
;
Christian,Lundtoft [11]
;
Claudia,Langenberg [12]
;
Maik,Pietzner [13]
;
Dennis,Valentine [14]
;
Stefano,Gustincich [15]
;
Gian Gaetano,Tartaglia [15]
;
Elias,Allara [16]
;
Praveen,Surendran [17]
;
Stephen,Burgess [18]
;
Jing Hua,Zhao [16]
;
James E,Peters [19]
;
Bram P,Prins [20]
;
Emanuele Di,Angelantonio [21]
;
Poornima,Devineni [5]
;
Yunling,Shi [5]
;
Kristine E,Lynch [22]
;
Scott L,DuVall [22]
;
Helene,Garcon [5]
;
Lauren O,Thomann [5]
;
Jin J,Zhou [23]
;
Bryan R,Gorman [5]
;
Jennifer E,Huffman [24]
;
Christopher J,O'Donnell [25]
;
Philip S,Tsao [26]
;
Jean C,Beckham [27]
;
Saiju,Pyarajan [5]
;
Sumitra,Muralidhar [28]
;
Grant D,Huang [28]
;
Rachel,Ramoni [28]
;
Pedro,Beltrao [10]
;
John,Danesh [21]
;
Adriana M,Hung [29]
;
Kyong-Mi,Chang [30]
;
Yan V,Sun [31]
;
Jacob,Joseph [32]
;
Andrew R,Leach [4]
;
Todd L,Edwards [33]
;
Kelly,Cho [34]
;
J Michael,Gaziano [34]
;
Adam S,Butterworth [35]
;
Juan P,Casas [36]
;
VA Million Veteran Program COVID-19 Science Initiative
作者单位：
Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.;BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
[1]
Central RNA Lab, Istituto Italiano di Tecnologia, Genoa, Italy.;Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
[2]
Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, São Paulo, Brazil.;Genetics Department, Harvard Medical School, Harvard University, Boston, MA, USA.
[3]
Chemical Biology, European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
[4]
Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
[5]
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
[6]
Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA.;Department of Population and Quantitative Health Sciences, Case Western Reserve University and Louis Stoke, Cleveland VA, Cleveland, OH, USA.
[7]
The Corporal Michael J. Crescenz VA Medical Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.;Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
[8]
Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.;Biostatistics, School of Public Health, Boston University, Boston, MA, USA.
[9]
European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
[10]
Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
[11]
Berlin Institute of Health, Charité University Medicine Berlin, Berlin, Germany.;MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
[12]
MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
[13]
Institute of Health Informatics, University College London, London, UK.;Health Data Research, University College London, London, UK.
[14]
Central RNA Lab, Istituto Italiano di Tecnologia, Genoa, Italy.
[15]
BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
[16]
BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.;British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.;Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.;Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
[17]
BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.;MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.
[18]
Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.;Centre for Inflammatory Disease, Dept of Immunology and Inflammation, Imperial College, London, UK.
[19]
BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.;Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.
[20]
BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.;British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.;Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.;National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.;National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK.
[21]
VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, UT, USA.;Department of Internal Medicine, Epidemiology, University of Utah, Salt Lake City, UT, USA.
[22]
Department of Epidemiology and Biostatistics, University of Arizona, Tucson, AZ, USA.;Phoenix VA Health Care System, Phoenix, AZ, USA.
[23]
Center for Population Genomics, Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
[24]
Cardiology, VA Boston Healthcare System, Boston, MA, USA.;Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
[25]
Epidemiology Research and Information Center (ERIC), VA Palo Alto Health Care System, Palo Alto, CA, USA.;Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.
[26]
MIRECC, Durham VA Medical Center, Durham, NC, USA.;Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA.
[27]
Office of Research and Development, Department of Veterans Affairs, Washington, DC, USA.
[28]
VA Tennessee Valley Healthcare System, Nashville, TN, USA.;Nephrology & Hypertension, Vanderbilt University, Nashville, TN, USA.
[29]
Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.;The Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
[30]
Atlanta VA Health Care System, Decatur, GA, USA.;Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.
[31]
Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.;Medicine, Cardiovascular, VA Boston Healthcare System and Brigham & Women's Hospital, Boston, MA, USA.
[32]
Department of Veterans Affairs, Tennessee Valley Healthcare System, Vanderbilt University, Nashville, TN, USA.;Medicine, Epidemiology, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
[33]
Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.;Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
[34]
BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. asb38@medschl.cam.ac.uk.;British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK. asb38@medschl.cam.ac.uk.;Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK. asb38@medschl.cam.ac.uk.;National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK. asb38@medschl.cam.ac.uk.;National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK. asb38@medschl.cam.ac.uk.
[35]
Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA. jpcasasromero@bwh.harvard.edu.;Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. jpcasasromero@bwh.harvard.edu.
[36]
医学主题词
药物重新定位(Drug Repositioning);全基因组关联研究(Genome-Wide Association Study);人类(Humans);白细胞介素10受体β亚单位(Interleukin-10 Receptor beta Subunit);孟德尔随机化分析(Mendelian Randomization Analysis);数量性状基因座位(Quantitative Trait Loci);受体, 干扰素αβ(Receptor, Interferon alpha-beta)
DOI
10.1038/s41591-021-01310-z
PMID
33837377
发布时间
2025-05-30
基金项目
I01 BX004821/BX/BLRD VA/United States
MR/L003120/1/MRC_/Medical Research Council/United Kingdom
RG/13/13/30194/BHF_/British Heart Foundation/United Kingdom
MC_UU_12015/1/MRC_/Medical Research Council/United Kingdom
I01 CX001897/CX/CSRD VA/United States
MR/S004068/2/MRC_/Medical Research Council/United Kingdom
MC_UU_00002/7/MRC_/Medical Research Council/United Kingdom
204623/Z/16/Z/WT_/Wellcome Trust/United Kingdom
WT_/Wellcome Trust/United Kingdom
RG/18/13/33946/BHF_/British Heart Foundation/United Kingdom
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