Silencing of SARS-CoV-2 with modified siRNA-peptide dendrimer formulation.

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第一作者： Musa,Khaitov

第一单位： NRC Institute of Immunology FMBA, Moscow, Russia.

作者： Musa,Khaitov ^[1] ; Alexandra,Nikonova ^[2] ; Igor,Shilovskiy ^[1] ; Ksenia,Kozhikhova ^[1] ; Ilya,Kofiadi ^[1] ; Lyudmila,Vishnyakova ^[1] ; Alexander,Nikolskii ^[1] ; Pia,Gattinger ^[3] ; Valeria,Kovchina ^[1] ; Ekaterina,Barvinskaia ^[1] ; Kirill,Yumashev ^[1] ; Valeriy,Smirnov ^[1] ; Artem,Maerle ^[1] ; Ivan,Kozlov ^[1] ; Artem,Shatilov ^[1] ; Anastasiia,Timofeeva ^[1] ; Sergey,Andreev ^[1] ; Olesya,Koloskova ^[1] ; Nadezhda,Kuznetsova ^[4] ; Daria,Vasina ^[4] ; Maria,Nikiforova ^[4] ; Sergei,Rybalkin ^[1] ; Ilya,Sergeev ^[1] ; Dmitriy,Trofimov ^[1] ; Alexander,Martynov ^[1] ; Igor,Berzin ^[5] ; Vladimir,Gushchin ^[4] ; Aleksey,Kovalchuk ^[6] ; Sergei,Borisevich ^[6] ; Rudolf,Valenta ^[7] ; Rakhim,Khaitov ^[1] ; Veronica,Skvortsova ^[5]

作者单位： NRC Institute of Immunology FMBA, Moscow, Russia. ^[1] NRC Institute of Immunology FMBA, Moscow, Russia.;Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia. ^[2] Medical University of Vienna, Vienna, Austria. ^[3] Federal State Budget Institution "National Research Centre for Epidemiology and Microbiology named after Honorary Academician N. F.Gamaleya" of the Ministry of Health of the Russian Federation, Moscow, Russia. ^[4] Federal Medico-biological Agency of Russia (FMBA Russia), Moscow, Russia. ^[5] 48 Central Research Institute of the Ministry of Defense of the Russian Federation, Moscow, Russia. ^[6] NRC Institute of Immunology FMBA, Moscow, Russia.;Medical University of Vienna, Vienna, Austria. ^[7]

关键词 COVID-19 LNA SARS-CoV-2 peptide dendrimers siRNA

主题词动物(Animals);抗病毒药(Antiviral Agents);树状聚合物(Dendrimers);人类(Humans);肽类(Peptides);RNA, 小分子干扰(RNA, Small Interfering);RNA, 病毒(RNA, Viral)

DOI 10.1111/all.14850

PMID 33837568

发布时间 2022-10-05

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