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HLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry.

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第一作者: Bettina,Konte
第一单位: Department of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle, Germany. bettina.konte@uk-halle.de.
作者单位: Department of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle, Germany. bettina.konte@uk-halle.de. [1] MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK. [2] Department of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle, Germany. [3] Department of Severe Mental Illness, Mental Health Care Organization North-Holland North, Heerhugowaard, The Netherlands. [4] Department of Pharmacology and Therapeutics, The University of Liverpool, Liverpool, England. [5] Department of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital, Kuopio, Finland.;Department of Clinical Neuroscience, Karolinska Institutet, and Center for Psychiatry Research, Stockholm City Council, Stockholm, Sweden. [6] Mental Health Services Rivierduinen, Oegstgeest, The Netherlands. [7] Department of Clinical Chemistry, St Jansdal Hospital, Harderwijk, The Netherlands.;Psychiatric Hospital GGz Centraal, Dependance Meerkanten, Ermelo, The Netherlands. [8] Department of Clinical Chemistry, St Jansdal Hospital, Harderwijk, The Netherlands. [9] Department of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital, Kuopio, Finland. [10] Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavík, Iceland.;Landspitali University Hospital, Mental Health Services, Hringbraut, 101 Reykjavik, Iceland. [11] Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, M5T 1R8, Canada.;Department of Psychiatry, University of Toronto, Toronto, ON, M5T 1R8, Canada.;Institute of Medical Science, University of Toronto, Toronto, ON, M5S 1A8, Canada. [12] Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE-17177, Sweden.;Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599-7264, USA.;Department of Psychiatry, University of North Carolina, Chapel Hill, NC, 27599-7160, USA. [13] Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. [14] King's College London, London, UK. [15] deCODE Genetics/Amgen, Reykjavik, Iceland. [16] SGDP Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.;Eli Lilly and Company, Bracknell, UK. [17]
DOI 10.1038/s41398-021-01322-w
PMID 33846298
发布时间 2025-01-06
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