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Synthetic repertoires derived from convalescent COVID-19 patients enable discovery of SARS-CoV-2 neutralizing antibodies and a novel quaternary binding modality.

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作者单位: Center for Systems and Synthetic Biology, Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA. [1] Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA. [2] U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA. [3] CCDC Army Research Laboratory, Biotechnology Branch, Adelphi, MD, USA. [4] National Center for Therapeutics Manufacturing, Texas A&M University, College Station, TX, USA. [5] CCDC Army Research Laboratory-South, Austin, TX, USA. [6] Department of Veterinary and Biomedical Science and Animal Diagnostic Laboratory, The Pennsylvania State University, University Park, Pennsylvania, USA. [7] Department of Agricultural and Biological Engineering, Texas A&M University, College Station, TX, USA. [8] Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA. [9] Department of Oncology, Dell Medical School, The University of Texas at Austin, Austin, TX, USA. [10] Department of Chemistry, The University of Texas at Austin, Austin, TX, USA. [11] Center for Molecular and Translational Human Infectious Diseases Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA. [12] Department of Animal Science and the Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA. [13]
DOI 10.1101/2021.04.07.438849
PMID 33851158
发布时间 2024-02-11
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