首页> Toxicology and applied pharmacology> Microtubule and tubulin binding and regulation of microtubule dynamics by the antibody drug conjugate (ADC) payload, monomethyl auristatin E (MMAE): Mechanistic insights into MMAE ADC peripheral neuropathy.

Microtubule and tubulin binding and regulation of microtubule dynamics by the antibody drug conjugate (ADC) payload, monomethyl auristatin E (MMAE): Mechanistic insights into MMAE ADC peripheral neuropathy.

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第一作者： Rebecca L,Best

第一单位： Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA.

作者： Rebecca L,Best ^[1] ; Nichole E,LaPointe ^[1] ; Olga,Azarenko ^[1] ; Herb,Miller ^[1] ; Christine,Genualdi ^[2] ; Stephen,Chih ^[1] ; Ben-Quan,Shen ^[3] ; Mary Ann,Jordan ^[1] ; Leslie,Wilson ^[1] ; Stuart C,Feinstein ^[4] ; Nicola J,Stagg ^[5]

作者单位： Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA. ^[1] Safety Assessment, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. ^[2] Preclinical and Translational PK, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. ^[3] Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA. Electronic address: feinstei@lifesci.ucsb.edu. ^[4] Safety Assessment, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: stagg.nicola@gene.com. ^[5]

关键词 Anti-cancer Antibody drug conjugate Auristatin Microtubule-targeting agent Peripheral nervous system Peripheral neuropathy