PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling.-论文-万方医学网

第一作者： Bing,Yao

第一单位： The State Key Laboratory of Pharmaceutical Biotechnology, Department of Hematology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, China-Australia Institute of Translational Medicine, School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing, 210023, China.;Department of Medical Genetics, Nanjing Medical University, Nanjing, China.

作者： Bing,Yao ^[1] ; Tao,Gui ^[2] ; Xiangwei,Zeng ^[2] ; Yexuan,Deng ^[2] ; Zhi,Wang ^[2] ; Ying,Wang ^[2] ; Dongjun,Yang ^[2] ; Qixiang,Li ^[2] ; Peipei,Xu ^[2] ; Ruifeng,Hu ^[2] ; Xinyu,Li ^[2] ; Bing,Chen ^[2] ; Jin,Wang ^[2] ; Ke,Zen ^[2] ; Haitao,Li ^[3] ; Melissa J,Davis ^[4] ; Marco J,Herold ^[4] ; Hua-Feng,Pan ^[5] ; Zhi-Wei,Jiang ^[5] ; David C S,Huang ^[4] ; Ming,Liu ^[6] ; Junyi,Ju ^[7] ; Quan,Zhao ^[8]

作者单位： The State Key Laboratory of Pharmaceutical Biotechnology, Department of Hematology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, China-Australia Institute of Translational Medicine, School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing, 210023, China.;Department of Medical Genetics, Nanjing Medical University, Nanjing, China. ^[1] The State Key Laboratory of Pharmaceutical Biotechnology, Department of Hematology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, China-Australia Institute of Translational Medicine, School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing, 210023, China. ^[2] Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Tsinghua-Peking Joint Center for Life Sciences, School of Medicine, Tsinghua University, Beijing, China. ^[3] The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia. ^[4] Department of General Surgery, the Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. ^[5] The State Key Laboratory of Pharmaceutical Biotechnology, Department of Hematology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, China-Australia Institute of Translational Medicine, School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing, 210023, China. liuming_nju@163.com. ^[6] The State Key Laboratory of Pharmaceutical Biotechnology, Department of Hematology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, China-Australia Institute of Translational Medicine, School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing, 210023, China. jujunyi@nju.edu.cn. ^[7] The State Key Laboratory of Pharmaceutical Biotechnology, Department of Hematology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, China-Australia Institute of Translational Medicine, School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing, 210023, China. qzhao@nju.edu.cn. ^[8]

医学主题词动物(Animals);精氨酸(Arginine);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);结直肠肿瘤(Colorectal Neoplasms);DNA解旋酶类(DNA Helicases);硫酸葡聚糖(Dextran Sulfate);疾病恶化(Disease Progression);组蛋白类(Histones);人类(Humans);甲基化(Methylation);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);模型, 生物学(Models, Biological);核蛋白质类(Nuclear Proteins);预后(Prognosis);蛋白质精氨酸N-甲基转移酶(Protein-Arginine N-Methyltransferases);阻遏蛋白质类(Repressor Proteins);信号传导(Signal Transduction);转录因子(Transcription Factors);转录, 遗传(Transcription, Genetic);增量调节(Up-Regulation)

DOI 10.1186/s13073-021-00871-5

PMID 33853662

发布时间 2022-01-18

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PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling.

Genome medicine

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PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling.

Genome medicine

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Genome medicine

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