Engineering of a Peptide α-N-Methyltransferase to Methylate Non-Proteinogenic Amino Acids.

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第一作者： Haigang,Song

第一单位： Division of Structural Biology, Wellcome Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, UK.;The Research Complex at Harwell, Harwell Campus, Oxford, OX11 0FA, UK.;The Rosalind Franklin Institute, Harwell Campus, Oxford, OX11 0FA, UK.

作者： Haigang,Song ^[1] ; Antony J,Burton ^[2] ; Sally L,Shirran ^[3] ; Jūratė,Fahrig-Kamarauskaitė ^[4] ; Hannelore,Kaspar ^[4] ; Tom W,Muir ^[2] ; Markus,Künzler ^[4] ; James H,Naismith ^[1]

作者单位： Division of Structural Biology, Wellcome Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, UK.;The Research Complex at Harwell, Harwell Campus, Oxford, OX11 0FA, UK.;The Rosalind Franklin Institute, Harwell Campus, Oxford, OX11 0FA, UK. ^[1] Department of Chemistry, Frick Chemistry Laboratory, Princeton University, Princeton, NJ, USA. ^[2] Biomedical Sciences Research Complex, North Haugh, University of St. Andrews, Fife, KY16 9ST, UK. ^[3] Department of Biology, Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Zürich, Switzerland. ^[4]

关键词 RiPPs cyclic peptide non-proteinogenic amino acids split intein α-N-methylation

主题词酰胺类(Amides);氨基酸类(Amino Acids);甲基化(Methylation);甲基转移酶类(Methyltransferases);肽类(Peptides);蛋白质构象(Protein Conformation);蛋白质工程(Protein Engineering)

DOI 10.1002/anie.202100818

PMID 33856715

发布时间 2021-09-15

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