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The dystonia gene THAP1 controls DNA double-strand break repair choice.

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第一作者： Kenta,Shinoda

第一单位： Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.

作者： Kenta,Shinoda ^[1] ; Dali,Zong ^[1] ; Elsa,Callen ^[1] ; Wei,Wu ^[1] ; Lavinia C,Dumitrache ^[2] ; Frida,Belinky ^[1] ; Raj,Chari ^[3] ; Nancy,Wong ^[1] ; Momoko,Ishikawa ^[1] ; Andre,Stanlie ^[1] ; Trisha,Multhaupt-Buell ^[4] ; Nutan,Sharma ^[4] ; Laurie,Ozelius ^[4] ; Michelle,Ehrlich ^[5] ; Peter J,McKinnon ^[2] ; André,Nussenzweig ^[6]

作者单位： Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA. ^[1] St. Jude Translational Neuroscience, Center for Pediatric Neurological Disease Research, Departments of Genetics and Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA. ^[2] Genome Modification Core, Frederick National Laboratory for Cancer Research, Frederick, MD, USA. ^[3] Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. ^[4] Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ^[5] Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA. Electronic address: andre_nussenzweig@nih.gov. ^[6]

关键词 BRCA1 SHLD1 THAP1 antibody class-switch recombination cancer dystonia homologous recombination non-homologous end joining resection transcriptional regulation