Exosome-mediated delivery of an anti-angiogenic peptide inhibits pathological retinal angiogenesis.-论文-万方医学网

作者： Xue,Dong ^[1] ; Yi,Lei ^[2] ; Zeyang,Yu ^[3] ; Tian,Wang ^[1] ; Yi,Liu ^[3] ; Gang,Han ^[2] ; Xiaodan,Zhang ^[3] ; Yiming,Li ^[1] ; Yinting,Song ^[3] ; Heping,Xu ^[2] ; Mei,Du ^[3] ; Haifang,Yin ^[4] ; Xiaohong,Wang ^[1] ; Hua,Yan ^[3]

作者单位： Department of Ophthalmology, Tianjin Medical University General Hospital, 300070, Tianjin, China. ^[1] Department of Pharmacology and Tianjin Key Laboratory of Inflammation Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, 300070, Tianjin, China. ^[2] Laboratory of Molecular Ophthalmology, Tianjin Medical University. ^[3] School of Medical Laboratory, Tianjin Medical University, Guangdong Road, Tianjin 300203, China. ^[4] The Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK. ^[5] Tianjin Key Laboratory of Cellular Homeostasis and Human Diseases & Department of Cell Biology, Tianjin Medical University, Qixiangtai Road, Heping District, Tianjin, 300070, China. ^[6]

主题词血管生成抑制剂(Angiogenesis Inhibitors);血管生成蛋白质类(Angiogenic Proteins);动物(Animals);毛细血管通透性(Capillary Permeability);细胞运动(Cell Movement);细胞增殖(Cell Proliferation);细胞, 培养的(Cells, Cultured);疾病模型, 动物(Disease Models, Animal);内皮细胞(Endothelial Cells);外泌体(Exosomes);人类(Humans);玻璃体内注射(Intravitreal Injections);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);新生血管化, 病理性(Neovascularization, Pathologic);氧(Oxygen);肽碎片(Peptide Fragments);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);视网膜(Retina);视网膜新生血管化(Retinal Neovascularization);信号传导(Signal Transduction);血管内皮生长因子A(Vascular Endothelial Growth Factor A)

DOI 10.7150/thno.54755

PMID 33859737

发布时间 2022-02-18

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Exosome-mediated delivery of an anti-angiogenic peptide inhibits pathological retinal angiogenesis.

Theranostics

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Exosome-mediated delivery of an anti-angiogenic peptide inhibits pathological retinal angiogenesis.

Theranostics

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Theranostics

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