首页> British journal of pharmacology> Olinciguat, a stimulator of soluble guanylyl cyclase, attenuates inflammation, vaso-occlusion and nephropathy in mouse models of sickle cell disease.

Olinciguat, a stimulator of soluble guanylyl cyclase, attenuates inflammation, vaso-occlusion and nephropathy in mouse models of sickle cell disease.

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第一作者： Boris,Tchernychev

第一单位： Cyclerion Therapeutics Inc., Boston, Massachusetts, USA.

作者： Boris,Tchernychev ^[1] ; Huihui,Li ^[2] ; Sung-Kyun,Lee ^[2] ; Xin,Gao ^[2] ; Raghunath,Ramanarasimhaiah ^[1] ; Guang,Liu ^[1] ; Katherine C,Hall ^[1] ; Sylvie G,Bernier ^[1] ; Juli E,Jones ^[1] ; Susanne,Feil ^[3] ; Robert,Feil ^[3] ; Emmanuel S,Buys ^[1] ; Regina M,Graul ^[1] ; Paul S,Frenette ^[2] ; Jaime L,Masferrer ^[1]

作者单位： Cyclerion Therapeutics Inc., Boston, Massachusetts, USA. ^[1] Departments of Medicine and Cell Biology, Albert Einstein College of Medicine, New York, New York, USA. ^[2] Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany. ^[3]

关键词 inflammation kidney injury olinciguat sickle cell disease soluble guanylate cyclase vaso-occlusive crisis

医学主题词贫血, 镰状细胞性(Anemia, Sickle Cell);动物(Animals);人类(Humans);炎症(Inflammation);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);血管疾病(Vascular Diseases)

DOI 10.1111/bph.15492

PMID 33864386

发布时间 2024-04-07

基金项目

1F32HL142243/NH/NIH HHS/United States R01 HL069438/HL/NHLBI NIH HHS/United States F32 HL142243/HL/NHLBI NIH HHS/United States R01 HL069438/NH/NIH HHS/United States R01 DK056638/DK/NIDDK NIH HHS/United States

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