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Modeling the impact of amino acid substitution in a monoclonal antibody on cation exchange chromatography.

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第一作者： David,Saleh

第一单位： Late Stage DSP Development, Boehringer Ingelheim, Biberach, Germany.;Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.

作者： David,Saleh ^[1] ; Rudger,Hess ^[1] ; Michelle,Ahlers-Hesse ^[2] ; Nicole,Beckert ^[3] ; Markus,Schönberger ^[2] ; Federico,Rischawy ^[1] ; Gang,Wang ^[2] ; Joschka,Bauer ^[3] ; Michaela,Blech ^[3] ; Simon,Kluters ^[2] ; Joey,Studts ^[2] ; Jürgen,Hubbuch ^[4]

作者单位： Late Stage DSP Development, Boehringer Ingelheim, Biberach, Germany.;Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany. ^[1] Late Stage DSP Development, Boehringer Ingelheim, Biberach, Germany. ^[2] Pharmaceutical Development Biologics, Boehringer Ingelheim, Biberach, Germany. ^[3] Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany. ^[4]

关键词 antibody purification cation exchange chromatography developability assessment mechanistic chromatography modeling protein surface analysis