LRRK2 G2019S kinase activity triggers neurotoxic NSF aggregation.

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作者： Francesca,Pischedda ^[1] ; Maria Daniela,Cirnaru ^[2] ; Luisa,Ponzoni ^[3] ; Michele,Sandre ^[4] ; Alice,Biosa ^[5] ; Maria Perez,Carrion ^[6] ; Oriano,Marin ^[1] ; Michele,Morari ^[7] ; Lifeng,Pan ^[5] ; Elisa,Greggio ^[8] ; Rina,Bandopadhyay ^[9] ; Mariaelvina,Sala ^[6] ; Giovanni,Piccoli ^[10]

作者单位： CIBIO, Università degli Studi di Trento, Trento, Italy. ^[1] Dulbecco Telethon Institute, Rome, Italy. ^[2] Icahn School of Medicine at Mount Sinai, New York, NY, USA. ^[3] CNR, Institute of Neuroscience, Milan, Italy. ^[4] Department of Biomedical Sciences (DSB), University of Padova, Padova, Italy. ^[5] Department of Biology, University of Padova, Padova, Italy. ^[6] Unidad Asociada Neurodeath, Faculty of Medicine, University of Castilla-La Mancha, 02008, Albacete, Spain. ^[7] Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Ferrara, Italy. ^[8] Shanghai Institute of Organic Chemistry, Shanghai, China. ^[9] Reta Lila Weston Institute of Neurological Studies and Department of Clinical and Movement Neuroscience, UCL Queen Square Institute of Neurology, London, UK. ^[10]

关键词 LRRK2 Parkinson's disease aggregation autophagy