第一单位：
Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.;Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.;Department of Neurological Surgery, Helen Diller Research Center, University of California San Francisco, San Francisco, CA, USA.
作者：
Abigail K,Suwala [1]
;
Damian,Stichel [2]
;
Daniel,Schrimpf [2]
;
Sybren L N,Maas [3]
;
Martin,Sill [4]
;
Hildegard,Dohmen [5]
;
Rouzbeh,Banan [6]
;
Annekathrin,Reinhardt [2]
;
Philipp,Sievers [2]
;
Felix,Hinz [2]
;
Mirjam,Blattner-Johnson [7]
;
Christian,Hartmann [8]
;
Leonille,Schweizer [9]
;
Henning B,Boldt [10]
;
Bjarne Winther,Kristensen [11]
;
Jens,Schittenhelm [12]
;
Matthew D,Wood [13]
;
Guillaume,Chotard [14]
;
Rolf,Bjergvig [15]
;
Anirban,Das [16]
;
Uri,Tabori [17]
;
Martin,Hasselblatt [18]
;
Andrey,Korshunov [19]
;
Zied,Abdullaev [20]
;
Martha,Quezado [20]
;
Kenneth,Aldape [20]
;
Patrick N,Harter [21]
;
Matija,Snuderl [22]
;
Jürgen,Hench [23]
;
Stephan,Frank [23]
;
Till,Acker [5]
;
Sebastian,Brandner [24]
;
Frank,Winkler [25]
;
Pieter,Wesseling [26]
;
Stefan M,Pfister [27]
;
David E,Reuss [2]
;
Wolfgang,Wick [25]
;
Andreas,von Deimling [2]
;
David T W,Jones [7]
;
Felix,Sahm [28]
作者单位：
Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.;Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.;Department of Neurological Surgery, Helen Diller Research Center, University of California San Francisco, San Francisco, CA, USA.
[1]
Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.;Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
[2]
Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.;Department of Pathology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
[3]
Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.;Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
[4]
Institute of Neuropathology, University of Giessen, Giessen, Germany.
[5]
Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
[6]
Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.;Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
[7]
Department of Neuropathology, Institute of Pathology, Hannover Medical School, Hannover, Germany.
[8]
Department of Neuropathology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.;German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany.
[9]
Department of Pathology, Odense University Hospital, Odense, Denmark.;Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
[10]
Department of Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.;Department of Clinical Medicine and Biotech Research and Innovation Center (BRIC), University of Copenhagen, Copenhagen, Denmark.
[11]
Institute of Pathology and Neuropathology, Department of Neuropathology, University Hospital Tübingen, Tübingen, Germany.
[12]
Department of Pathology, Oregon Health and Science University, Portland, OR, USA.
[13]
Department of Pathology, Hospital Center University of Bordeaux, Bordeaux, France.
[14]
Department of Biomedicine, University of Bergen, Bergen, Norway.
[15]
Division of Haematology/Oncology, The Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G 1X8, Canada.
[16]
Division of Haematology/Oncology, The Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G 1X8, Canada.;The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Canada.;Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Canada.
[17]
Institute of Neuropathology, University Hospital Münster, Munster, Germany.
[18]
Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.;Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.;Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
[19]
Laboratory of Pathology, National Cancer Institute Centre for Cancer Research, Bethesda, MD, USA.
[20]
Neurological Institute (Edinger Institute), Goethe-University Frankfurt am Main, Frankfurt am Main, Germany.;Frankfurt Cancer Institute (FCI), Frankfurt am Main, Germany.;German Cancer Research Center (DKFZ), Heidelberg, Germany.
[21]
Division of Neuropathology, NYU Langone Health, New York, USA.;Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, USA.;Division of Molecular Pathology and Diagnostics, NYU Langone Health, New York, USA.
[22]
Division of Neuropathology, Institute of Pathology, Basel University Hospital, Basel, Switzerland.
[23]
Division of Neuropathology, The National Hospital for Neurology and Neurosurgery, University College London Hospitals, London, UK.;Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London, UK.
[24]
Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.;Department of Neurology and Neurooncology Program, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.
[25]
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.;Department of Pathology, Amsterdam University Medical Centers/VUmc and Brain Tumor Center Amsterdam, Amsterdam, The Netherlands.
[26]
Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.;Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.;Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, Heidelberg, Germany.
[27]
Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany. Felix.Sahm@med.uni-heidelberg.de.;Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany. Felix.Sahm@med.uni-heidelberg.de.;Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany. Felix.Sahm@med.uni-heidelberg.de.
[28]
主题词
脑肿瘤(Brain Neoplasms);染色体, 人, 1对(Chromosomes, Human, Pair 1);染色体, 人, 7对(Chromosomes, Human, Pair 7);队列研究(Cohort Studies);周期素依赖激酶抑制剂p16(Cyclin-Dependent Kinase Inhibitor p16);DNA拷贝数变异(DNA Copy Number Variations);DNA甲基化(DNA Methylation);女(雌)性(Female);基因缺失(Gene Deletion);神经胶质原纤维酸性蛋白质(Glial Fibrillary Acidic Protein);胶质母细胞瘤(Glioblastoma);人类(Humans);男(雄)性(Male);中年人(Middle Aged);神经外胚瘤, 原始(Neuroectodermal Tumors, Primitive);PTEN磷酸水解酶(PTEN Phosphohydrolase);视网膜母细胞瘤结合蛋白类(Retinoblastoma Binding Proteins);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53);泛素蛋白连接酶类(Ubiquitin-Protein Ligases)
DOI
10.1007/s00401-021-02302-6
PMID
33876327
发布时间
2022-02-16
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