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Haem is crucial for medium-dependent metronidazole resistance in clinical isolates of Clostridioides difficile.

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第一作者： Ilse M,Boekhoud

第一单位： Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.

作者： Ilse M,Boekhoud ^[1] ; Igor,Sidorov ^[1] ; Sam,Nooij ^[2] ; Céline,Harmanus ^[1] ; Ingrid M J G,Bos-Sanders ^[1] ; Virginie,Viprey ^[3] ; William,Spittal ^[3] ; Emma,Clark ^[3] ; Kerrie,Davies ^[4] ; Jane,Freeman ^[4] ; Ed J,Kuijper ^[5] ; Wiep Klaas,Smits ^[6] ; COMBACTE-CDI Consortium

作者单位： Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands. ^[1] Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.;Center for Microbiome Analyses and Therapeutics, Leiden University Medical Center, Leiden, The Netherlands. ^[2] Healthcare Associated Infection Research Group, School of Medicine, University of Leeds, Leeds, UK. ^[3] Healthcare Associated Infection Research Group, School of Medicine, University of Leeds, Leeds, UK.;European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Study Group for Clostridioides difficile (ESGCD), Basel, Switzerland. ^[4] Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.;European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Study Group for Clostridioides difficile (ESGCD), Basel, Switzerland.;National Institute for Public Health and the Environment, Bilthoven, The Netherlands. ^[5] Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.;Center for Microbiome Analyses and Therapeutics, Leiden University Medical Center, Leiden, The Netherlands.;European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Study Group for Clostridioides difficile (ESGCD), Basel, Switzerland. ^[6]