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Single-cell multi-omics analysis of the immune response in COVID-19.

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作者: Emily,Stephenson [1] ; Gary,Reynolds [1] ; Rachel A,Botting [1] ; Fernando J,Calero-Nieto [2] ; Michael D,Morgan [3] ; Zewen Kelvin,Tuong [4] ; Karsten,Bach [3] ; Waradon,Sungnak [5] ; Kaylee B,Worlock [6] ; Masahiro,Yoshida [6] ; Natsuhiko,Kumasaka [5] ; Katarzyna,Kania [7] ; Justin,Engelbert [1] ; Bayanne,Olabi [1] ; Jarmila Stremenova,Spegarova [8] ; Nicola K,Wilson [2] ; Nicole,Mende [2] ; Laura,Jardine [1] ; Louis C S,Gardner [1] ; Issac,Goh [1] ; Dave,Horsfall [1] ; Jim,McGrath [1] ; Simone,Webb [1] ; Michael W,Mather [1] ; Rik G H,Lindeboom [5] ; Emma,Dann [5] ; Ni,Huang [5] ; Krzysztof,Polanski [5] ; Elena,Prigmore [5] ; Florian,Gothe [9] ; Jonathan,Scott [8] ; Rebecca P,Payne [8] ; Kenneth F,Baker [10] ; Aidan T,Hanrath [11] ; Ina C D,Schim van der Loeff [8] ; Andrew S,Barr [12] ; Amada,Sanchez-Gonzalez [12] ; Laura,Bergamaschi [13] ; Federica,Mescia [13] ; Josephine L,Barnes [6] ; Eliz,Kilich [14] ; Angus,de Wilton [14] ; Anita,Saigal [15] ; Aarash,Saleh [15] ; Sam M,Janes [16] ; Claire M,Smith [17] ; Nusayhah,Gopee [18] ; Caroline,Wilson [19] ; Paul,Coupland [7] ; Jonathan M,Coxhead [1] ; Vladimir Yu,Kiselev [5] ; Stijn,van Dongen [5] ; Jaume,Bacardit [20] ; Hamish W,King [21] ; Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID-19 BioResource Collaboration [22] ; Anthony J,Rostron [8] ; A John,Simpson [8] ; Sophie,Hambleton [2] ; Elisa,Laurenti [13] ; Paul A,Lyons [5] ; Kerstin B,Meyer [16] ; Marko Z,Nikolić [11] ; Christopher J A,Duncan [13] ; Kenneth G C,Smith [23] ; Sarah A,Teichmann [24] ; Menna R,Clatworthy [25] ; John C,Marioni [26] ; Berthold,Göttgens [27] ; Muzlifah,Haniffa
作者单位: Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK. [1] Wellcome - MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. [2] European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, UK.;Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK. [3] Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK.;Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK. [4] Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK. [5] UCL Respiratory, Division of Medicine, University College London, London, UK. [6] Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK. [7] Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK. [8] Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.;Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany. [9] Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.;NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. [10] Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.;Department of Infection and Tropical Medicine, Newcastle upon Tyne Hospitals NHS Foundation, Newcastle upon Tyne, UK. [11] Department of Infection and Tropical Medicine, Newcastle upon Tyne Hospitals NHS Foundation, Newcastle upon Tyne, UK. [12] Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.;Department of Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK. [13] University College London Hospitals NHS Foundation Trust, London, UK. [14] Royal Free Hospital NHS Foundation Trust, London, UK. [15] UCL Respiratory, Division of Medicine, University College London, London, UK.;University College London Hospitals NHS Foundation Trust, London, UK. [16] UCL Great Ormond Street Institute of Child Health, London, UK. [17] Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.;Department of Dermatology, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. [18] Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.;The Innovation Lab Integrated COVID Hub North East, Newcastle Upon Tyne, UK. [19] School of Computing, Newcastle University, Newcastle Upon Tyne, UK. [20] Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.;Centre for Immunobiology, Blizard Institute, Queen Mary University of London, London, UK. [21] Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.;Integrated Critical Care Unit, Sunderland Royal Hospital, South Tyneside and Sunderland NHS Foundation Trust, Sunderland, UK. [22] Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK. st9@sanger.ac.uk.;Theory of Condensed Matter Group, Cavendish Laboratory/Department of Physics, University of Cambridge, Cambridge, UK. st9@sanger.ac.uk. [23] Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK. mrc38@cam.ac.uk.;Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK. mrc38@cam.ac.uk.;Department of Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK. mrc38@cam.ac.uk.;Cambridge Institute for Therapeutic Immunology and Infectious Disease, Cambridge Biomedical Campus, Cambridge, UK. mrc38@cam.ac.uk.;NIHR Cambridge Biomedical Research Centre, Cambridge, UK. mrc38@cam.ac.uk. [24] European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, UK. marioni@ebi.ac.uk.;Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK. marioni@ebi.ac.uk.;Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK. marioni@ebi.ac.uk. [25] Wellcome - MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. bg200@cam.ac.uk. [26] Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK. m.a.haniffa@ncl.ac.uk.;Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK. m.a.haniffa@ncl.ac.uk.;NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. m.a.haniffa@ncl.ac.uk.;Department of Dermatology, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. m.a.haniffa@ncl.ac.uk. [27]
DOI 10.1038/s41591-021-01329-2
PMID 33879890
发布时间 2024-08-10
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