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Isoform-specific and signaling-dependent propagation of acute myeloid leukemia by Wilms tumor 1.

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第一作者： Sandeep,Potluri

第一单位： Institute of Cancer and Genomic Sciences, College of Medicine and Dentistry, University of Birmingham, Edgbaston, Birmingham B152TT, UK. Electronic address: s.potluri@bham.ac.uk.

作者： Sandeep,Potluri ^[1] ; Salam A,Assi ^[2] ; Paulynn S,Chin ^[2] ; Dan J L,Coleman ^[2] ; Anna,Pickin ^[2] ; Shogo,Moriya ^[3] ; Naohiko,Seki ^[4] ; Olaf,Heidenreich ^[5] ; Peter N,Cockerill ^[2] ; Constanze,Bonifer ^[6]

作者单位： Institute of Cancer and Genomic Sciences, College of Medicine and Dentistry, University of Birmingham, Edgbaston, Birmingham B152TT, UK. Electronic address: s.potluri@bham.ac.uk. ^[1] Institute of Cancer and Genomic Sciences, College of Medicine and Dentistry, University of Birmingham, Edgbaston, Birmingham B152TT, UK. ^[2] Department of Biochemistry and Genetics, Chiba University Graduate School of Medicine, Chiba, Japan. ^[3] Department of Functional Genomics, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan. ^[4] Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Herschel Building, Level 6, Brewery Lane, Newcastle upon Tyne NE1 7RU, UK; Prinses Máxima Centrum for Pediatric Oncology, Postbus 113, 3720 AC Bilthoven, Heidelberglaan 25, 3584CS Utrecht, the Netherlands. ^[5] Institute of Cancer and Genomic Sciences, College of Medicine and Dentistry, University of Birmingham, Edgbaston, Birmingham B152TT, UK. Electronic address: c.bonifer@bham.ac.uk. ^[6]

关键词 FLT3-ITD AML WT1 binding motif WT1 isoforms Wilms tumour 1 acute myeloid leukemia chromatin early growth response factors gene regulatory networks oncogenic signaling t(8;21) AML transcription