Synthesis and structure-activity relationships of new chiral spiro-β-lactams highly active against HIV-1 and Plasmodium.

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作者： Nuno Guerreiro,Alves ^[1] ; Inês,Bártolo ^[2] ; Américo J S,Alves ^[1] ; Diana,Fontinha ^[3] ; Denise,Francisco ^[3] ; Susana M M,Lopes ^[1] ; Maria I L,Soares ^[1] ; Carlos J V,Simões ^[4] ; Miguel,Prudêncio ^[3] ; Nuno,Taveira ^[5] ; Teresa M V D,Pinho E Melo ^[6]

作者单位： University of Coimbra, Coimbra Chemistry Centre and Department of Chemistry, 3004-535, Coimbra, Portugal. ^[1] Instituto de Investigação Do Medicamento (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal. ^[2] Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028 Lisboa, Portugal. ^[3] University of Coimbra, Coimbra Chemistry Centre and Department of Chemistry, 3004-535, Coimbra, Portugal; BSIM Therapeutics, Instituto Pedro Nunes, Coimbra, Portugal. ^[4] Instituto de Investigação Do Medicamento (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal; Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Universitário Egas Moniz (IUEM), Caparica, Portugal. ^[5] University of Coimbra, Coimbra Chemistry Centre and Department of Chemistry, 3004-535, Coimbra, Portugal. Electronic address: tmelo@ci.uc.pt. ^[6]

关键词 1,3-Dipolar cycloaddition 2-Butynoates Allenes Anti-HIV agents Antiplasmodial agents Phosphane-catalyzed [3+2] annulations Spiro-3H-pyrazole-β-lactams Spiro-penicillanates Spirocyclic compounds Spirocyclopentenyl-β-lactams β-Lactams