Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing.

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作者： Emilie,Marhuenda ^[1] ; Christine,Fabre ^[2] ; Cunjie,Zhang ^[3] ; Martà,Martin-Fernandez ^[4] ; Thomas,Iskratsch ^[5] ; Ali,Saleh ^[6] ; Luc,Bauchet ^[7] ; Julien,Cambedouzou ^[8] ; Jean-Philippe,Hugnot ^[9] ; Hugues,Duffau ^[4] ; James W,Dennis ^[4] ; David,Cornu ^[10] ; Norbert,Bakalara ^[5]

作者单位： Institut des Neurosciences de Montpellier (INM) U-1051, University of Montpellier, 80 rue Augustin Fliche, Hôpital Saint-Eloi, 34091, Montpellier, Cedex 5, France. e.marhuenda@qmul.ac.uk. ^[1] School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK. e.marhuenda@qmul.ac.uk. ^[2] Institut Européen des Membranes, IEM, UMR 5635, University of Montpellier, ENSCM, CNRS, Montpellier, France. e.marhuenda@qmul.ac.uk. ^[3] Institut des Neurosciences de Montpellier (INM) U-1051, University of Montpellier, 80 rue Augustin Fliche, Hôpital Saint-Eloi, 34091, Montpellier, Cedex 5, France. ^[4] École nationale supérieure de chimie de Montpellier, ENSCM, 240 Avenue du Professeur Emile Jeanbrau, 34090, Montpellier, France. ^[5] Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Ave., Toronto, ON, M5G 1X5, Canada. ^[6] Department of Molecular Genetics, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, M5S 1A8, Canada. ^[7] Institut Charles Coulomb, UMR 5221, University of Montpellier, CNRS, Montpellier, France. ^[8] School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK. ^[9] Institut Européen des Membranes, IEM, UMR 5635, University of Montpellier, ENSCM, CNRS, Montpellier, France. ^[10] Institut Européen des Membranes, IEM, UMR 5635, University of Montpellier, ENSCM, CNRS, Montpellier, France. david.cornu@enscm.fr. ^[11] École nationale supérieure de chimie de Montpellier, ENSCM, 240 Avenue du Professeur Emile Jeanbrau, 34090, Montpellier, France. david.cornu@enscm.fr. ^[12] Institut des Neurosciences de Montpellier (INM) U-1051, University of Montpellier, 80 rue Augustin Fliche, Hôpital Saint-Eloi, 34091, Montpellier, Cedex 5, France. norbert.bakalara@enstbb.fr. ^[13] École nationale supérieure de chimie de Montpellier, ENSCM, 240 Avenue du Professeur Emile Jeanbrau, 34090, Montpellier, France. norbert.bakalara@enstbb.fr. ^[14]

关键词 3D-nanofibre scaffold Biomaterial EMT Focal adhesion Galectin Glioblastoma Glycosylation Mechanotransduction Mgat5 Migration Stiffness

主题词脑肿瘤(Brain Neoplasms);细胞运动(Cell Movement);胶质母细胞瘤(Glioblastoma);人类(Humans);N-乙酰氨基葡糖转移酶类(N-Acetylglucosaminyltransferases);肿瘤干细胞(Neoplastic Stem Cells);表型(Phenotype)

DOI 10.1186/s13046-021-01925-7

PMID 33894774

发布时间 2023-09-20

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