Development of a scalable and robust AEX method for enriched rAAV preparations in genome-containing VCs of serotypes 5, 6, 8, and 9.

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作者： Pranav R H,Joshi ^[1] ; Alice,Bernier ^[1] ; Pablo D,Moço ^[1] ; Joseph,Schrag ^[2] ; Parminder S,Chahal ^[2] ; Amine,Kamen ^[1]

作者单位： Viral Vectors and Vaccine Bioprocessing Group, Department of Bioengineering, McGill University, Montreal, QC, Canada. ^[1] Human Health Therapeutics, National Research Council of Canada, Montreal, QC, Canada. ^[2]

关键词 AAV serotype-5, 6, 8, 9 AAV vectors anion-exchange chromatography downstream processing gene therapy scale-up separation of genome containing/empty AAV capsids

DOI 10.1016/j.omtm.2021.03.016

PMID 33898632

发布时间 2021-04-28

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Molecular therapy. Methods & clinical development

2021年21卷

341-356页

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Development of a scalable and robust AEX method for enriched rAAV preparations in genome-containing VCs of serotypes 5, 6, 8, and 9.

Molecular therapy. Methods & clinical development

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Molecular therapy. Methods & clinical development

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Development of a scalable and robust AEX method for enriched rAAV preparations in genome-containing VCs of serotypes 5, 6, 8, and 9.

Molecular therapy. Methods & clinical development

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Molecular therapy. Methods & clinical development

相关期刊

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