首页> Annals of hematology> Genome-wide DNA methylation analysis pre- and post-lenalidomide treatment in patients with myelodysplastic syndrome with isolated deletion (5q).

Genome-wide DNA methylation analysis pre- and post-lenalidomide treatment in patients with myelodysplastic syndrome with isolated deletion (5q).

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第一作者： Anna,Hecht

第一单位： Department of Hematology and Oncology, University Hospital Mannheim, Mannheim, Germany. anna.hecht@medma.uni-heidelberg.de.

作者： Anna,Hecht ^[1] ; Julia A,Meyer ^[2] ; Johann-Christoph,Jann ^[3] ; Katja,Sockel ^[4] ; Aristoteles,Giagounidis ^[5] ; Katharina S,Götze ^[6] ; Anne,Letsch ^[7] ; Detlef,Haase ^[8] ; Richard F,Schlenk ^[9] ; Torsten,Haferlach ^[10] ; Philippe,Schafhausen ^[11] ; Gesine,Bug ^[12] ; Michael,Lübbert ^[13] ; Felicitas,Thol ^[14] ; Guntram,Büsche ^[15] ; Esther,Schuler ^[16] ; Verena,Nowak ^[3] ; Julia,Obländer ^[3] ; Stephanie,Fey ^[3] ; Nadine,Müller ^[3] ; Georgia,Metzgeroth ^[3] ; Wolf-Karsten,Hofmann ^[3] ; Ulrich,Germing ^[16] ; Florian,Nolte ^[3] ; Mark,Reinwald ^[17] ; Daniel,Nowak ^[3]

作者单位： Department of Hematology and Oncology, University Hospital Mannheim, Mannheim, Germany. anna.hecht@medma.uni-heidelberg.de. ^[1] Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA. ^[2] Department of Hematology and Oncology, University Hospital Mannheim, Mannheim, Germany. ^[3] Department of Hematology, University Hospital Dresden, Dresden, Germany. ^[4] Department of Hematology, Oncology and Palliative Care, Marien Hospital Duesseldorf, Duesseldorf, Germany. ^[5] Department of Internal Medicine, Technical University of Munich, Munich, Germany. ^[6] Department of Hematology and Oncology, Charité, Benjamin Franklin University, Berlin, Germany. ^[7] Clinics of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany. ^[8] Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany. ^[9] MLL Munich Leukemia Laboratory, Munich, Germany. ^[10] Department of Oncology, Hematology, BMT with section Pneumology, Hubertus Wald Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. ^[11] Department of Internal Medicine, University Hospital Frankfurt, Frankfurt, Germany. ^[12] Internal Medicine, University Hospital Freiburg, Freiburg, Germany. ^[13] Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany. ^[14] Hannover Medical School, Institute of Pathology, Hannover, Germany. ^[15] Department for Hematology, Oncology and Clinical Immunology, University Hospital, Heinrich-Heine-University, Duesseldorf, Germany. ^[16] Brandenburg Medical School Theodor Fontane, Brandenburg an der Havel, Germany. ^[17]

关键词 DNA methylation Deletion 5q Lenalidomide Myelodysplastic syndromes

医学主题词成年人(Adult);老年人(Aged);老年人, 80以上(Aged, 80 and over);抗肿瘤药(Antineoplastic Agents);染色体缺失(Chromosome Deletion);染色体, 人, 5对(Chromosomes, Human, Pair 5);DNA甲基化(DNA Methylation);女(雌)性(Female);人类(Humans);男(雄)性(Male);中年人(Middle Aged);骨髓增生异常综合征(Myelodysplastic Syndromes);治疗结果(Treatment Outcome)

DOI 10.1007/s00277-021-04492-1

PMID 33903952

发布时间 2024-10-28

基金项目

NO817/5-2/Deutsche Forschungsgemeinschaft 70113953/Deutsche Krebshilfe M83/H.W. & J. Hector Fund Project 20/2016/Dr. Rolf M. Schwiete Fund DJCLS H 03/01/José Carreras Leukämie-Stiftung

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