首页> The Journal of clinical investigation> Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts.

Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts.

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第一作者： Sonakshi,Bhattacharjee

第一单位： Department of Medicine, Columbia University, New York, New York, USA.

作者： Sonakshi,Bhattacharjee ^[1] ; Florian,Hamberger ^[2] ; Aashreya,Ravichandra ^[1] ; Maximilian,Miller ^[3] ; Ajay,Nair ^[1] ; Silvia,Affo ^[1] ; Aveline,Filliol ^[1] ; LiKang,Chin ^[4] ; Thomas M,Savage ^[5] ; Deqi,Yin ^[1] ; Naita Maren,Wirsik ^[6] ; Adam,Mehal ^[1] ; Nicholas,Arpaia ^[7] ; Ekihiro,Seki ^[8] ; Matthias,Mack ^[9] ; Di,Zhu ^[10] ; Peter A,Sims ^[11] ; Raghu,Kalluri ^[12] ; Ben Z,Stanger ^[4] ; Kenneth P,Olive ^[1] ; Thomas,Schmidt ^[6] ; Rebecca G,Wells ^[4] ; Ingmar,Mederacke ^[2] ; Robert F,Schwabe ^[13]

作者单位： Department of Medicine, Columbia University, New York, New York, USA. ^[1] Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hanover, Germany. ^[2] Department of Biochemistry and Microbiology, Rutgers University, New Brunswick, New Jersey, USA. ^[3] Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. ^[4] Department of Microbiology and Immunology, Columbia University, New York, New York, USA. ^[5] Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Heidelberg University, Heidelberg, Germany. ^[6] Department of Microbiology and Immunology, Columbia University, New York, New York, USA.;Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, USA. ^[7] Department of Medicine, Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, California, USA. ^[8] Department of Nephrology, University Hospital Regensburg, Regensburg, Germany. ^[9] Department of Pharmacology, Minhang Hospital and School of Pharmacy, Fudan University, Shanghai, China. ^[10] Department of Systems Biology, Columbia University, New York, New York, USA. ^[11] Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. ^[12] Department of Medicine, Columbia University, New York, New York, USA.;Institute of Human Nutrition, Columbia University, New York, New York, USA. ^[13]

关键词 Cancer Collagens Fibrosis Hepatology Oncology

医学主题词动物(Animals);细胞系, 肿瘤(Cell Line, Tumor);胶原Ⅰ型(Collagen Type I);肝星状细胞(Hepatic Stellate Cells);人类(Humans);肝肿瘤, 实验性(Liver Neoplasms, Experimental);动力传导, 细胞(Mechanotransduction, Cellular);小鼠, 基因敲除(Mice, Knockout);肿瘤转移(Neoplasm Metastasis);小鼠(Mice)

DOI 10.1172/JCI146987

PMID 33905375

发布时间 2024-09-23

基金项目

P01 CA117969/CA/NCI NIH HHS/United States R01 DK085252/DK/NIDDK NIH HHS/United States U54 CA193417/CA/NCI NIH HHS/United States R01 CA190844/CA/NCI NIH HHS/United States P30 CA013696/CA/NCI NIH HHS/United States P01 CA233452/CA/NCI NIH HHS/United States R01 CA228483/CA/NCI NIH HHS/United States

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