Exploration of 7-azaindole-coumaranone hybrids and their analogues as protein kinase inhibitors.

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作者： Malikotsi A,Qhobosheane ^[1] ; Richard M,Beteck ^[1] ; Blandine,Baratte ^[2] ; Thomas,Robert ^[2] ; Sandrine,Ruchaud ^[3] ; Stéphane,Bach ^[4] ; Lesetja J,Legoabe ^[5]

作者单位： Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa. ^[1] Sorbonne Université, CNRS, UMR8227, Integrative Biology of Marine Models Laboratory (LBI2M), Station Biologique de Roscoff, 29680, Roscoff, France; Sorbonne Université, CNRS, FR2424, Plateforme de Criblage KISSf (Kinase Inhibitor Specialized Screening Facility), Station Biologique de Roscoff, 29680, Roscoff Cedex, France. ^[2] Sorbonne Université, CNRS, UMR8227, Integrative Biology of Marine Models Laboratory (LBI2M), Station Biologique de Roscoff, 29680, Roscoff, France. ^[3] Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa; Sorbonne Université, CNRS, UMR8227, Integrative Biology of Marine Models Laboratory (LBI2M), Station Biologique de Roscoff, 29680, Roscoff, France; Sorbonne Université, CNRS, FR2424, Plateforme de Criblage KISSf (Kinase Inhibitor Specialized Screening Facility), Station Biologique de Roscoff, 29680, Roscoff Cedex, France. ^[4] Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa. Electronic address: lesetja.legoabe@nwu.ac.za. ^[5]

关键词 7-Azaindole Anticancer drugs Coumaranone GSK-3β Haspin Leishmanicidal drugs LmCK1 Polypharmacology Protein kinase