Hedgehog interacting protein (HHIP) represses airway remodeling and metabolic reprogramming in COPD-derived airway smooth muscle cells.-论文-万方医学网

第一作者： Yan,Li

第一单位： School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong Province, China. yanli.sdu@gmail.com.

作者： Yan,Li ^[1] ; Li,Zhang ^[2] ; Francesca,Polverino ^[3] ; Feng,Guo ^[4] ; Yuan,Hao ^[5] ; Taotao,Lao ^[6] ; Shuang,Xu ^[4] ; Lijia,Li ^[4] ; Betty,Pham ^[7] ; Caroline A,Owen ^[4] ; Xiaobo,Zhou ^[4]

作者单位： School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong Province, China. yanli.sdu@gmail.com. ^[1] Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA. yanli.sdu@gmail.com. ^[2] Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong Province, China. yanli.sdu@gmail.com. ^[3] Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA. ^[4] Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China. ^[5] Asthma and Airway Disease Research Center, University of Arizona, Medicine, Tucson, AZ, 85724, USA. ^[6] Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, 02129, USA. ^[7] Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA. ^[8] Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA. xiaobo.zhou@channing.harvard.edu. ^[9] Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA. xiaobo.zhou@channing.harvard.edu. ^[10]

主题词成年人(Adult);气道重塑(Airway Remodeling);动物(Animals);载体蛋白质类(Carrier Proteins);细胞增殖(Cell Proliferation);女(雌)性(Female);糖酵解(Glycolysis);单倍剂量不足(Haploinsufficiency);人类(Humans);肺(Lung);男(雄)性(Male);膜糖蛋白类(Membrane Glycoproteins);膜蛋白质类(Membrane Proteins);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 突变型(Mice, Mutant Strains);中年人(Middle Aged);肌细胞, 平滑肌(Myocytes, Smooth Muscle);肺疾病, 慢性阻塞性(Pulmonary Disease, Chronic Obstructive);甲状腺激素类(Thyroid Hormones);小鼠(Mice)

DOI 10.1038/s41598-021-88434-x

PMID 33907231

发布时间 2024-05-04

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Hedgehog interacting protein (HHIP) represses airway remodeling and metabolic reprogramming in COPD-derived airway smooth muscle cells.

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Hedgehog interacting protein (HHIP) represses airway remodeling and metabolic reprogramming in COPD-derived airway smooth muscle cells.

Scientific reports

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Scientific reports

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