Deletion of a non-canonical regulatory sequence causes loss of Scn1a expression and epileptic phenotypes in mice.-论文-万方医学网

第一作者： Jessica L,Haigh

第一单位： Department of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, CA, USA.;Department of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, CA, USA.

作者： Jessica L,Haigh ^[1] ; Anna,Adhikari ^[2] ; Nycole A,Copping ^[2] ; Tyler,Stradleigh ^[1] ; A Ayanna,Wade ^[1] ; Rinaldo,Catta-Preta ^[1] ; Linda,Su-Feher ^[1] ; Iva,Zdilar ^[1] ; Sarah,Morse ^[1] ; Timothy A,Fenton ^[2] ; Anh,Nguyen ^[1] ; Diana,Quintero ^[1] ; Samrawit,Agezew ^[1] ; Michael,Sramek ^[1] ; Ellie J,Kreun ^[1] ; Jasmine,Carter ^[1] ; Andrea,Gompers ^[1] ; Jason T,Lambert ^[1] ; Cesar P,Canales ^[1] ; Len A,Pennacchio ^[3] ; Axel,Visel ^[4] ; Diane E,Dickel ^[3] ; Jill L,Silverman ^[5] ; Alex S,Nord ^[6]

作者单位： Department of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, CA, USA.;Department of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, CA, USA. ^[1] Department of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, CA, USA.;MIND Institute and Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine, Sacramento, CA, USA. ^[2] Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.;U.S. Department of Energy Joint Genome Institute, Walnut Creek, CA, USA.;Comparative Biochemistry Program, University of California, Berkeley, Berkeley, CA, USA. ^[3] Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.;U.S. Department of Energy Joint Genome Institute, Walnut Creek, CA, USA.;Comparative Biochemistry Program, University of California, Berkeley, Berkeley, CA, USA.;School of Natural Sciences, University of California, Merced, CA, USA. ^[4] Department of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, CA, USA. jsilverman@ucdavis.edu.;MIND Institute and Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine, Sacramento, CA, USA. jsilverman@ucdavis.edu. ^[5] Department of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, CA, USA. asnord@ucdavis.edu.;Department of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, CA, USA. asnord@ucdavis.edu. ^[6]

医学主题词动物(Animals);注意力(Attention);碱基序列(Base Sequence);脑(Brain);染色质(Chromatin);保守序列(Conserved Sequence);疾病模型, 动物(Disease Models, Animal);脑电描记术(Electroencephalography);癫痫(Epilepsy);进化, 分子(Evolution, Molecular);女(雌)性(Female);基因表达调控(Gene Expression Regulation);HEK293细胞(HEK293 Cells);杂合子(Heterozygote);纯合子(Homozygote);人类(Humans);男(雄)性(Male);迷宫学习(Maze Learning);记忆障碍(Memory Disorders);小鼠, 近交C57BL(Mice, Inbred C57BL);神经元(Neurons);表型(Phenotype);蛋白质结合(Protein Binding);调控序列, 核酸(Regulatory Sequences, Nucleic Acid);序列缺失(Sequence Deletion);存活率分析(Survival Analysis);温度(Temperature);反式激活因子类(Trans-Activators);小鼠(Mice)

DOI 10.1186/s13073-021-00884-0

PMID 33910599

发布时间 2024-02-26

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Deletion of a non-canonical regulatory sequence causes loss of Scn1a expression and epileptic phenotypes in mice.

Genome medicine

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Deletion of a non-canonical regulatory sequence causes loss of Scn1a expression and epileptic phenotypes in mice.

Genome medicine

相似文献

同项目论文

Genome medicine

相关期刊

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